Transcriptomic and Macroscopic Architectures of Multimodal Covariance Network Reveal Molecular–Structural–Functional Co-alterations  

作　　者：Lin Jiang Yueheng Peng Runyang He Qingqing Yang Chanlin Yi Yuqin Li Bin Zhu Yajing Si Tao Zhang Bharat B.Biswal Dezhong Yao Lan Xiong Fali Li Peng Xu 

机构地区：[1]The Clinical Hospital of Chengdu Brain Science Institute,MOE Key Lab for Neuroinformation,University of Electronic Science and Technology of China,Chengdu 611731,China [2]School of Life Science and Technology,Center for Information in BioMedicine,University of Electronic Science and Technology of China,Chengdu 611731,China [3]School of Psychology,Xinxiang Medical University,Xinxiang 453003,China [4]School of Science,Xihua University,Chengdu 610039,China [5]Department of Biomedical Engineering,New Jersey Institute of Technology,Newark,NJ,USA [6]School of Electrical Engineering,Zhengzhou University,Zhengzhou 450001,China [7]Research Unit of NeuroInformation,Chinese Academy of Medical Sciences,2019RU035,Chengdu,China [8]Montreal Neurological Institute and Hospital,McGill University,Montreal,QC,Canada [9]Department of Electrical and Computer Engineering,Faculty of Science and Technology,University of Macao,Macao,China [10]Radiation Oncology Key Laboratory of Sichuan Province,610041 Chengdu,China [11]Rehabilitation Center,Qilu Hospital of Shandong University,Jinan 250012,China

出　　处：《Research》2024年第1期471-487,共17页研究（英文）

基　　金：the STI 2030-Major Projects(#2022ZD0208500,#2022ZD02114000,and#2022ZD0208900);the National Natural Science Foundation of China(#62103085,#61961160705,#U19A2082,and#62006197);the Science and Technology Development Fund,Macao SAR(file no.0045/2019/AFJ);the Key R&D Projects of Science&Technology Department of Sichuan Province(#23ZDYF0961);the Scientific Research Foundation of Sichuan Provincial People's Hospital(#2021LY21).

摘　　要：Human cognition is usually underpinned by intrinsic structure and functional neural co-activation in spatially distributed brain regions.Owing to lacking an effective approach to quantifying the covarying of structure and functional responses,how the structural–functional circuits interact and how genes encode the relationships,to deepen our knowledge of human cognition and disease,are still unclear.Here,we propose a multimodal covariance network(MCN)construction approach to capture interregional covarying of the structural skeleton and transient functional activities for a single individual.We further explored the potential association between brain-wide gene expression patterns and structural–functional covarying in individuals involved in a gambling task and individuals with major depression disorder(MDD),adopting multimodal data from a publicly available human brain transcriptomic atlas and 2 independent cohorts.MCN analysis showed a replicable cortical structural–functional fine map in healthy individuals,and the expression of cognition-and disease phenotype-related genes was found to be spatially correlated with the corresponding MCN differences.Further analysis of cell type-specific signature genes suggests that the excitatory and inhibitory neuron transcriptomic changes could account for most of the observed correlation with task-evoked MCN differences.

关 键 词：alterations EVOKED spatially 

分 类 号：R741[医药卫生—神经病学与精神病学]