Acceptor Engineering Produces Ultrafast Nonradiative Decay in NIR-Ⅱ Aza-BODIPY Nanoparticles for Efficient Osteosarcoma Photothermal Therapy via Concurrent Apoptosis and Pyroptosis  

作　　者：Zhenxiong Shi Hua Bai Jiaxing Wu Xiaofei Miao Jia Gao Xianning Xu Yi Liu Jiamin Jiang Jiaqi Yang Jiaxin Zhang Tao Shao Bo Peng Huili Ma Dan Zhu Guojing Chen Wenbo Hu Lin Li Wei Huang 

机构地区：[1]Frontiers Science Center for Flexible Electronics,Xi’an Institute of Flexible Electronics(IFE)and Xi’an Institute of Biomedical Materials&Engineering,Northwestern Polytechnical University,Xi’an 710072,China [2]Key Laboratory for Organic Electronics and Information Displays&Institute of Advanced Materials(IAM),Nanjing University of Posts&Telecommunications,Nanjing 210023,China [3]Key Laboratory of Flexible Electronics(KLOFE)and IAM,Nanjing Tech University,Nanjing 211800,China [4]Britton Chance Center for Biomedical Photonics-MoE Key Laboratory for Biomedical Photonics,Wuhan National Laboratory for Optoelectronics-Advanced Biomedical Imaging Facility,Huazhong University of Science and Technology,Wuhan 430074,China [5]Department of Orthopedics,Xijing Hospital,The Fourth Military Medical University,Xi’an 710032,China [6]The Institute of Flexible Electronics(IFE,Future Technologies),Xiamen University,Xiamen 361005,China

出　　处：《Research》2024年第1期625-635,共11页研究（英文）

基　　金：the National Key R&D Program of China(2020YFA0709900);the National Natural Science Foundation of China(62288102,22077101,62175201,and 22004099);the Joint Research Funds of Department of Science&Technology of Shaanxi Province and North-western Polytechnical University(2020GXLH-Z-008,2020GXLH-Z-021 and 2020GXLH-Z-023);the Open Project Program of Wuhan National Laboratory for Optoelectronics(Nos.2020WNLOKF023 and 2022WNLOKF009);The Natural Science Foundation of Ningbo(202003N4049 and 202003N4065);the Natural Science Foundation of Shaanxi Province(2022JM-130).

摘　　要：Small-molecule photothermal agents(PTAs)with intense second near-infrared(NIR-Ⅱ,1,000 to 1,700 nm)absorption and high photothermal conversion efficiencies(PCEs)are promising candidates for treating deep-seated tumors such as osteosarcoma.To date,the development of small-molecule NIR-Ⅱ PTAs has largely relied on fabricating donor–acceptor–donor(D–A–D/D′)structures and limited success has been achieved.Herein,through acceptor engineering,a donor–acceptor–acceptor(D–A–A′)-structured NIR-Ⅱ aza-boron-dipyrromethene(aza-BODIPY)PTA(SW8)was readily developed for the 1,064-nm laser-mediated phototheranostic treatment of osteosarcoma.Changing the donor groups to acceptor groups produced remarkable red-shifts of absorption maximums from first near-infrared(NIR-Ⅰ)regions(~808 nm)to NIR-Ⅱ ones(~1,064 nm)for aza-BODIPYs(SW1 to SW8).Furthermore,SW8 self-assembled into nanoparticles(SW8@NPs)with intense NIR-Ⅱ absorption and an ultrahigh PCE(75%,1,064 nm).This ultrahigh PCE primarily originated from an additional nonradiative decay pathway,which showed a 100-fold enhanced decay rate compared to that shown by conventional pathways such as internal conversion and vibrational relaxation.Eventually,SW8@NPs performed highly efficient 1,064-nm laser-mediated NIR-Ⅱ photothermal therapy of osteosarcoma via concurrent apoptosis and pyroptosis.This work not only illustrates a remote approach for treating deep-seated tumors with high spatiotemporal control but also provides a new strategy for building high-performance small-molecule NIR-Ⅱ PTAs.

关 键 词：DONOR BODIPY INTENSE 

分 类 号：R738.1[医药卫生—肿瘤]