血浆热休克蛋白90α表达对老年原发性肝癌患者经导管肝动脉化疗栓塞术后预后的预测价值  

Predictive Value of Plasma Heat Shock Protein 90α Expression on the Prognosis of Transcatheter Arterial Chemoembolization in Elderly Patients with Primary Liver Cancer

作　　者：姜成毅 于军[2] 刘璐 李旭[3] 孙志强[1] Jiang Chengyi;Yu Jun;Liu Lu;Li Xu;Sun Zhiqiang(Jilin Cancer Hospital,Changchun 130102;School of Basic Medicine,Jilin University,Changchun 130012;The First Clinical Hospitalof Jilin University,Changchun 130012)

机构地区：[1]吉林省肿瘤医院,长春130102 [2]吉林大学基础医学院,长春130012 [3]吉林大学第一临床医院,长春130012

出　　处：《国际老年医学杂志》2024年第3期320-324,共5页International Journal of Geriatrics

基　　金：吉林省卫生健康科技能力提升项目(2021LC132)。

摘　　要：目的 探讨血浆中热休克蛋白90α(Hsp90α)在老年原发性肝癌患者经导管肝动脉化疗栓塞术(TACE)后预后评估中的价值。方法 选取2020年2月-2022年2月就诊于吉林省肿瘤医院高新院区综合外科介入组的110例老年原发性肝癌患者进行回顾性分析。采用ELISA法检测术前血浆中Hsp90α表达情况,以60 ng/mL作为截断值,分为Hsp90α高表达组(55例)和Hsp90α低表达组(37例)。采用Kaplan-Meier法绘制生存曲线,Log-rank检验比较生存曲线的差异。采用多因素Cox回归模型分析血浆中Hsp90α表达与TACE治疗的老年原发性肝癌预后的关系。结果 Hsp90α高表达组的2年总生存及无进展生存的累积生存率均低于Hsp90α低表达组(P<0.05)。多因素Cox回归分析结果显示:Hsp90α高表达是影响患者总生存及无进展生存的独立危险因素(P<0.05)。结论 老年原发性肝癌患者血浆Hsp90α表达水平可作为接受TACE治疗后短期预后的独立预测因子。Objective To investigate the value of plasma heat shock protein 90α(Hsp90α)in the prognostic assessment of elderly patients with primary hepatocellular carcinoma(HCC)after transcatheter arterial chemoembolization(TACE).Methods A retrospective analysis was conducted on 110 elderly patients diagnosed with primary HCC who underwent TACE in the Interventional Department of the High-tech Zone of Jilin Cancer Hospital from February 2020 to February 2022.The expression of Hsp90αin preoperative plasma was detected using ELISA,with a cut-off value of 60 ng/mL.Patients were divided into the high Hsp90αexpression group(55 cases)and the low Hsp90αexpression group(37 cases).Kaplan-Meier method was used to draw survival curves,and the Log-rank test was used to compare the differences in survival curves.Multivariate Cox regression analysis was performed to analyze the relationship between plasma Hsp90αexpression and the prognosis of elderly patients with primary HCC treated with TACE.Results The cumulative survival rates of two-year overall survival and progression-free survival in the high Hsp90αexpression group were lower than those in the low Hsp90αexpression group(P<0.05).Multivariate Cox regression analysis results showed that high Hsp90αexpression was an independent risk factor affecting overall survival and progression-free survival in patients(P<0.05).Conclusion The expression level of plasma Hsp90αin elderly patients with primary HCC can serve as an independent predictive factor for short-term prognosis after receiving TACE treatment.

关 键 词：原发性肝癌 经导管肝动脉化疗栓塞术 热休克蛋白90Α 

分 类 号：R735.7[医药卫生—肿瘤]