卵巢癌组织SOX9和SOX11表达水平及与患者预后的关系  

Expression of SOX9 and SOX11 in ovarian cancer tissue and their relationship with prognosis

作　　者：郑晗 马丽丽[1] 贺笑茜 冯碧波[2] ZHENG Han;MA Lili;HE Xiaoxi;FENG Bibo(Department of Gynecology and Obstetrics,Beijing Daxing District People's Hospital,Beijing 102600,China;Department of Gynecology and Obstetrics,Beijing Tongren Hospital,Capital Medical University,Beijing 100000,China)

机构地区：[1]北京市大兴区人民医院妇产科,北京102600 [2]首都医科大学附属北京同仁医院妇产科,北京100000

出　　处：《热带医学杂志》2024年第2期235-239,共5页Journal of Tropical Medicine

基　　金：吴阶平医学基金会临床科研专项资助基金(320.6750.2021-04-46)。

摘　　要：目的探讨卵巢癌组织性别决定基因盒9(SOX9)、性别决定基因盒11(SOX11)表达水平及与患者预后的关系。方法选取2018年7月-2020年6月于北京市大兴区人民医院行手术治疗的143例卵巢癌患者为研究对象,其中136例患者接受3年随访,根据3年生存情况分为生存组(n=85)和死亡组(n=51)。实时荧光定量PCR检测卵巢癌组织和癌旁组织中SOX9、SOX11表达水平;Kaplan-Meier法绘制生存曲线;多因素Cox回归模型分析影响卵巢癌患者预后的因素;受试者工作特征(ROC)曲线分析卵巢癌组织中SOX9和SOX11水平对患者预后的预测价值。结果卵巢癌组织中SOX9和SOX11表达水平较癌旁组织升高,差异均有统计学意义(t=29.530、27.908,P均<0.05)。死亡组卵巢癌组织中SOX9和SOX11表达水平较生存组卵巢癌组织升高,差异均有统计学意义(t=8.080、9.341,P均<0.05)。生存组和死亡组在分化程度、肿瘤直径、淋巴结转移和国际妇产科联盟(FIGO)分期方面比较差异均有统计学意义(χ^(2)=6.170、4.077、9.353、12.455,P均<0.05)。SOX9高表达组3年生存率(48.61%)低于SOX9低表达组(78.13%),SOX11高表达组3年生存率(51.43%)低于SOX11低表达组(74.24%),差异均有统计学意义(χ^(2)=14.202、9.032,P均<0.05)。SOX9、SOX11、分化程度、淋巴结转移、FIGO分期为卵巢癌患者预后的影响因素(HR=1.367、1.382、1.329、3.154、3.463,P均<0.05)。ROC结果显示,SOX9表达水平预测卵巢癌患者预后的曲线下面积(AUC)为0.803,灵敏度为66.67%,特异度为85.88%;SOX11表达水平预测卵巢癌患者预后的AUC为0.784,灵敏度为68.63%,特异度为87.06%;SOX9和SOX11联合预测卵巢癌患者预后的AUC(0.869)显著大于SOX9表达水平单独预测的AUC和SOX11表达水平单独预测的AUC,差异均有统计学意义(Z=2.099、2.294,P=0.036、0.022)。结论SOX9和SOX11在卵巢癌组织中高表达,二者联合对卵巢癌患者预后具有较高的预测价值。Objective To investigate the expression of sex⁃determining region Y box 9(SOX9)and sex⁃determining region Y box 11(SOX11)in ovarian cancer tissue and their relationship with prognosis.Methods From July 2018 to June 2020,143 ovarian cancer patients who underwent surgical treatment in the Beijing Daxing District People's Hospital were collected as the study subjects.Among them,136 patients underwent a 3⁃year follow⁃up and were separated into a survival group(n=85)and a death group(n=51)based on their 3⁃year survival status.Real⁃time fluorescence quantitative PCR(qRT⁃PCR)was applied to detect the expression levels of SOX9 and SOX11 in ovarian cancer tissues and adjacent tissues.Kaplan⁃Meier method was applied to plot survival curves;multi factor Cox regression model was applied to analyze the factors that affected the prognosis of ovarian cancer patients.Receiver operating characteristic(ROC)curve was applied to analyze the predictive value of SOX9 and SOX11 levels in ovarian cancer tissue for prognosis.Results The expression levels of SOX9 and SOX11 in ovarian cancer tissue were higher than those in adjacent tissues;all the differences were statistically significant(t=29.530,27.908;all P<0.05).The expression levels of SOX9 and SOX11 in ovarian cancer tissues in the death group were higher than those in adjacent tissues;all the differences were statistically significant(t=8.080,9.341;all P<0.05).There was a statistically obvious difference between the survival group and the death group in terms of differentiation,tumor diameter,lymph node metastasis,and Federation International of Gynecology and Obstetrics(FIGO)staging;all the differences were statistically significant(χ^(2)=6.170,4.077,9.353,12.455;all P<0.05).The 3⁃year survival rate of the SOX9 high expression group(48.61%)was lower than that of the SOX9 low expression group(78.13%);the 3⁃year survival rate of the SOX11 high expression group(51.43%)was lower than that of the SOX11 low expression group(74.24%);all the differences were statisti

关 键 词：卵巢癌 性别决定基因盒9 性别决定基因盒11 预后 

分 类 号：R737.31[医药卫生—肿瘤]