Bile acid signaling in the regulation of whole body metabolic and immunological homeostasis  

作　　者：Wei Jia Yitao Li Kenneth C.P.Cheung Xiaojiao Zheng 

机构地区：[1]School of Chinese Medicine,Hong Kong Baptist University,Hong Kong,China [2]Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus,Shanghai Sixth People's Hospital Affiliated to Shanghai JiaoTong University School of Medicine,Shanghai 200233,China

出　　处：《Science China(Life Sciences)》2024年第5期865-878,共14页中国科学（生命科学英文版）

基　　金：supported by the National Natural Science Foundation of China(82122012,82270917);Shanghai Research Center for Endocrine and Metabolic Diseases(2022ZZ01002)。

摘　　要：Bile acids(BAs)play a crucial role in nutrient absorption and act as key regulators of lipid and glucose metabolism and immune homeostasis.Through the enterohepatic circulation,BAs are synthesized,metabolized,and reabsorbed,with a portion entering the vascular circulation and distributing systemically.This allows BAs to interact with receptors in all major organs,leading to organ-organ interactions that regulate both local and global metabolic processes,as well as the immune system.This review focuses on the whole-body effects of BA-mediated metabolic and immunological regulation,including in the brain,heart,liver,intestine,eyes,skin,adipose tissue,and muscle.Targeting BA synthesis and receptor signaling is a promising strategy for the development of novel therapies for various diseases throughout the body.

关 键 词：bile acid whole body METABOLISM IMMUNITY 

分 类 号：R392[医药卫生—免疫学]