部分ESCRT亚基通过调控STING的降解调节其活性  

A specific module of ESCRT regulates STING activity termination by controlling STING degradation

作　　者：赵远 周晨暄 田文敏 陈杨 赵冲冲 栗妍 王世宣 荣岳光 Yuan Zhao;Chenxuan Zhou;Wenmin Tian;Yang Chen;Chongchong Zhao;Yan Li;Shixuan Wang;Yueguang Rong(School of Basic Medicine,Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease,Huazhong University of Science and Technology,Wuhan 430030,China;Center for Precision Medicine Multi-Omics Research,Peking University Health Science Center,Peking University,Beijing 100191,China;School of Basic Medical Sciences,Peking University Health Science Center,Peking University,Beijing 100083,China;The State Key Laboratory of Membrane Biology,Tsinghua University-Peking University Joint Center for Life Sciences,School of Life Sciences,Tsinghua University,Beijing 100084,China;The HIT Center for Life Sciences,Harbin Institute of Technology,Harbin 150080,China;Department of Obstetrics and Gynecology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Cell Architecture Research Center,Huazhong University of Science and Technology,Wuhan 430030,China)

机构地区：[1]School of Basic Medicine,Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease,Huazhong University of Science and Technology,Wuhan 430030,China [2]Center for Precision Medicine Multi-Omics Research,Peking University Health Science Center,Peking University,Beijing 100191,China [3]School of Basic Medical Sciences,Peking University Health Science Center,Peking University,Beijing 100083,China [4]The State Key Laboratory of Membrane Biology,Tsinghua University-Peking University Joint Center for Life Sciences,School of Life Sciences,Tsinghua University,Beijing 100084,China [5]The HIT Center for Life Sciences,Harbin Institute of Technology,Harbin 150080,China [6]Department of Obstetrics and Gynecology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China [7]Cell Architecture Research Center,Huazhong University of Science and Technology,Wuhan 430030,China

出　　处：《Science Bulletin》2024年第8期1000-1005,共6页科学通报（英文版）

基　　金：supported by the National Natural Science Foundation of China(92254302,91854116,31771529 and 32170685);the Fundamental Research Funds for the Central Universities(5003510089 and 2023BR028)。

摘　　要：Stimulator of interferon genes(STING),also known as MITA,ERIS,MPYS or TMEM173,is a key player in innate immunity,specifically in the typeⅠinterferon response[1-3].It is also involved in a range of non-canonical biological functions,including autophagy,cellular metabolism,translation,and DNA repair,and has implications in many diseases[4-9].After activation by its ligands,STING translocates from endoplasmic reticulum(ER),via ERGIC,Golgi apparatus and endosomes,finally to lysosomes for degradation[4-9].However,the mechanisms by which STING is delivered to lysosomes and whether this delivery process regulates STING activity remain elusive.

关 键 词：HAS finally IMMUNITY 

分 类 号：R392[医药卫生—免疫学]