仿生细胞膜涂层包覆肿瘤阻断代谢物传输  

Bioinspired cytomembrane coating besieges tumor for blocking metabolite transportation

作　　者：贾庆岩 岳子林 李元滢 张云秀 张建红 聂仁浩 李鹏 Qingyan Jia;Zilin Yue;Yuanying Li;Yunxiu Zhang;Jianhong Zhang;Renhao Nie;Peng Li(Frontiers Science Center for Flexible Electronics(FSCFE),Xi’an Institute of Flexible Electronics(IFE)and Xi’an Institute of Biomedical Materials&Engineering(IBME),Northwestern Polytechnical University,Xi’an 710072,China;Key Laboratory of Flexible Electronics of Zhejiang Province,Ningbo Institute of Northwestern Polytechnical University,Ningbo 315103,China;School of Flexible Electronics(SoFE)and Henan Institute of Flexible Electronics(HIFE),Henan University,Zhengzhou 450046,China)

机构地区：[1]Frontiers Science Center for Flexible Electronics(FSCFE),Xi’an Institute of Flexible Electronics(IFE)and Xi’an Institute of Biomedical Materials&Engineering(IBME),Northwestern Polytechnical University,Xi’an 710072,China [2]Key Laboratory of Flexible Electronics of Zhejiang Province,Ningbo Institute of Northwestern Polytechnical University,Ningbo 315103,China [3]School of Flexible Electronics(SoFE)and Henan Institute of Flexible Electronics(HIFE),Henan University,Zhengzhou 450046,China

出　　处：《Science Bulletin》2024年第7期933-948,共16页科学通报（英文版）

基　　金：supported by the National Natural Science Foundation of China(52273302 and 52073230);the Ningbo Natural Science Foundation(2021J050);the Shaanxi Provincial Science Fund for Distinguished Young Scholars(2023-JC-JQ-32);the Fundamental Research Funds for the Central Universities,China。

摘　　要：The metabolite transport inhibition of tumor cells holds promise to achieve anti-tumor efficacy.Herein,we presented an innovative strategy to hinder the delivery of metabolites through the in-situ besieging tumor cells with polyphenolic polymers that strongly adhere to the cytomembrane of tumor cells.Simultaneously,these polymers underwent self-crosslinking under the induction of tumor oxidative stress microenvironment to form an adhesive coating on the surface of the tumor cells.This polyphenol coating effectively obstructed glucose uptake,reducing metabolic products such as lactic acid,glutathione,and adenosine triphosphate,while also causing reactive oxygen species to accumulate in the tumor cells.The investigation of various tumor models,including 2D cells,3D multicellular tumor spheroids,and xenograft tumors,demonstrated that the polyphenolic polymers effectively inhibited the growth of tumor cells by blocking key metabolite transport processes.Moreover,this highly adhesive coating could bind tumor cells to suppress their metastasis and invasion.This work identified polyphenolic polymers as a promising anticancer candidate with a mechanism by impeding the mass transport of tumor cells.

关 键 词：Tumor treatment Metabolic inhibition Starvation therapy Polyphenol polymer Tumor microenvironment 

分 类 号：R73-3[医药卫生—肿瘤]