金黄仓鼠在临床医学中的研究进展  

The Recent Progress of Golden Hamsters in Clinical Medicine

作　　者：邱晨 李建民[1,2,3,4] QIU Chen;LI Jianmin(State Key Laboratory of Reproductive Medicine and Offspring Health,Nanjing Medical University,Nanjing 211166,China;Jiangsu Laboratory Animal Center,Jiangsu Animal Experimental Center of Medicine and Pharmacy,Animal Core facility,Key Laboratory of Model Animal,Nanjing Medical University,Nanjing 211166,China;Department of Cell Biology,School of Basic Medical Sciences,Nanjing Medical University,Nanjing 211166,China;Collaborative Innovation Centerfor Cardiovascular Disease Translational Medicine,Nanjing Medical University,Nanjing 211166,China)

机构地区：[1]南京医科大学生殖医学与子代健康全国重点实验室,南京211166 [2]江苏省医药动物实验基地,南京医科大学医药实验动物中心,江苏省实验动物中心,南京医科大学,南京211166 [3]南京医科大学基础医学院细胞生物学系,南京211166 [4]江苏省心血管病转化医学协同创新中心,南京医科大学,南京211166

出　　处：《中国细胞生物学学报》2024年第4期748-759,共12页Chinese Journal of Cell Biology

基　　金：国家重点研发计划(批准号:2021YFF0702500)资助的课题。

摘　　要：动物模型是临床医学和新药研究的重要支撑条件。尽管小鼠模型应用广泛,但近年来的研究显示,小鼠并不能完全模拟人类疾病,亟需新的动物模型弥补小鼠在各类研究中的不足。相比于小鼠,金黄仓鼠(golden hamster,Syrian hamster),在生殖、肿瘤、病毒学、脂代谢及心血管疾病等研究领域均显示,其基因表达与人具有较高的相似性。随着基因编辑技术的进步,金黄仓鼠在临床研究中的应用得以进一步拓展。该综述重点探讨基因编辑金黄仓鼠在生殖医学、脂代谢及心血管疾病、传染病、肿瘤等研究领域的最新进展,阐明基因编辑金黄仓鼠模型在医学研究的应用,以助于更好地理解基因在人类健康和疾病中的作用。Animal models are essential for clinical medical research and new drug discovery.While the mouse model remains a primary animal model,recent evidence has highlighted its limitations in accurately reflecting human diseases.The development of alternative animal models is critical to overcome these obstacles in a variety of fields.Golden hamsters(Syrian hamsters)emerge as superior models for human disease studies in areas like reproduction,oncology,virology,lipid metabolism and cardiovascular diseases,due to their closer alignment with human gene expression patterns compared to mice.The advancement of gene editing techniques has further expanded the utility of golden hamsters as models for a range of human diseases.This review focuses on reproductive medicine,lipid metabolism and cardiovascular diseases,infectious diseases,and oncology,with an emphasis on the use of gene-edited golden hamsters in medical research to enhance the understanding of the role of genes in human health and diseases.

关 键 词：金黄仓鼠 基因编辑 不孕不育 脂代谢 新冠 肿瘤 

分 类 号：R-332[医药卫生]