UE参数、S-TK1、AG490、WIP1诊断TC  

Diagnostic value of UE parameters,S-TK1,AG490 and WIP1 in TC

作　　者：施小燕[1] 田颖颖 Shi Xiaoyan;Tian Yingying(Department of Ultrasound,Rugao People's Hospital,Nantong,Jiangsu 226500)

机构地区：[1]如皋市人民医院超声科,江苏南通226500

出　　处：《现代科学仪器》2024年第2期108-112,共5页Modern Scientific Instruments

摘　　要：目的:探究UE参数、S-TK1、AG490、WIP1对甲状腺癌(TC)的诊断价值。方法:选择我院收治TC患者102例(TC组)和同期收治甲状腺结节良性患者73例(对照组)。比较两组UE参数、S-TK1、AG490、WIP1,分析各指标对TC的诊断价值。结果:TC组的弹性评分、SR值、S-TK1、WIP1水平均高于对照组,AG490低于对照组(P<0.05);ROC曲线分析发现五项指标联合诊断TC的AUC最高(P<0.05)。结论:UE参数与S-TK1、WIP1、AG490联合检测有利于临床诊断TC。Objective:To explore the diagnostic value of ultrasonic elastography(UE)parameters,serum thymidine kinase 1(S-TK1),AG490 and wild-type p53 induced phosphatase 1(WIP1)in thyroid cancer(TC).Methods:A total of 102 patients with TC and 73 patients with benign thyroid nodules in the hospital were enrolled as TC group and control group,respectively.UE parameters,S-TK1,AG490 and WIP1 were compared between the two groups,and their diagnostic value for TC was analyzed.Results:Elastography score,SR value,levels of S-TK1 and WIP1 in TC group were higher than those in control group,while AG490 was lower than that in control group(P<0.05).ROC curves analysis showed that AUC value of combined detection(all the above 5 indexes)in the diagnosis of TC was the greatest(P<0.05).Conclusion:Combined detection of UE parameters,S-TK1,WIP1 and AG490 is conducive to the clinical diagnosis of TC.

关 键 词：甲状腺癌 超声弹性成像 血清胸苷激酶1 AG490 野生型p53诱导的磷酸酶1 

分 类 号：R736.1[医药卫生—肿瘤]