磁共振成像在儿童脑智发育研究中的应用及挑战  

Application and challenges of magnetic resonance imaging in childhood brain development

作　　者：桂一丁 孙晓宁 王广海 江帆[1,2,3] GUI Yiding;SUN Xiaoning;WANG Guanghai;JIANG Fan(Department of Developmental and Behavioral Pediatrics,Shanghai Children’s Medical Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China;MOE-Shanghai Key Laboratory of Children’s Environmental Health,Xinhua Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China;Shanghai Center for Brain Science and Brain-Inspired Technology,Shanghai 201602,China;School of Psychology,Shanghai Jiao Tong University,Shanhai 200030,China;Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China)

机构地区：[1]上海交通大学医学院附属上海儿童医学中心发育行为儿科,上海200127 [2]上海交通大学医学院附属新华医院教育部和上海市环境与儿童健康重点实验室,上海200092 [3]上海脑科学与类脑研究中心,上海201602 [4]上海交通大学心理学院,上海200030 [5]上海交通大学医学院附属上海精神卫生中心,上海200030

出　　处：《教育生物学杂志》2024年第2期85-91,共7页Journal of Bio-education

基　　金：上海市市级科技重大专项(2018SHZDZX05);上海市卫生健康委2020年“生命早期健康与疾病”协同创新集群项目(2020CXJQ01);雀巢营养科学中心项目;上海市高水平地方高校建设创新团队:脑认知原理解析经费支持(SHSMU-ZDCX20211900);上海交通大学医学院高水平创新团队:社交障碍的神经机制及其干预策略(SHSMU-ZDCX20211100)。

摘　　要：儿童时期是脑智发育的关键阶段,探索这一阶段脑智发育的规律和影响因素具有重要意义。随着技术的发展,磁共振成像已成为儿童脑智研究的首选脑成像方法。该文综述了不同的磁共振成像方法(结构、功能、质子波谱)及相关脑影像指标在揭示儿童脑发育规律中的作用,并指出在儿童中开展磁共振成像研究所面临的挑战。Childhood is a critical stage of brain development,so exploring the patterns and related influencing factors of brain development during this stage is of great significance.With the development of brain imaging techniques,magnetic resonance imaging(MRI)has become the preferred imaging method for children.This paper reviewed different MRI modalities(structural and functional MRI and proton magnetic resonance spectroscopy),and roles of related brain imaging indicators in revealing the developmental patterns of children’s brain,and indicated current challenges of MRI studies in children.

关 键 词：脑科学 磁共振成像 脑智发育 婴幼儿 青少年 儿童发展 

分 类 号：R179[医药卫生—妇幼卫生保健] R445.2[医药卫生—公共卫生与预防医学]