聚卡波非钙片联合减量复方电解质散对肠道准备效果的影响  

Effect of calcium polycarbophil combined with reduced dosage of compound electrolyte powder on intestinal preparation

作　　者：王婷[1] 李兴华[1] WANG Ting;LI Xinghua(Department of Gastroenterology,Shanghai Eighth People′s Hospital,Shanghai 200235,China)

机构地区：[1]上海市第八人民医院消化内科,上海200235

出　　处：《江苏大学学报（医学版）》2024年第3期254-259,共6页Journal of Jiangsu University：Medicine Edition

基　　金：上海市军民融合发展专项资金科技创新支持项目(2019-jmrh1-kj53)。

摘　　要：目的:探讨聚卡波非钙联合复方聚乙二醇电解质散(polyethylene glycol electrolyte powder,PEG)在结肠镜检查前肠道准备的清洁效果。方法:选择2021年11月至2022年10月于上海市第八人民医院消化内镜中心行结肠镜检查的患者225例,随机均分成3组,分别为4 L-PEG组、2 L-PEG+聚卡波非钙组、4 L-PEG+聚卡波非钙组,每组75例;记录Aronchick评分、Boston肠道准备评分量表(Boston bowel preparation scale,BBPS)、息肉及腺瘤等病变检出率、袪泡效果评分、患者耐受率、再次接受意愿程度、不良反应事件,并进行统计分析。结果:与2 L-PEG+聚卡波非钙组和4 L-PEG组比较,4 L-PEG+聚卡波非钙组Aronchick评分明显降低(P<0.05),BBPS评分(总分、左半侧、中侧、右半侧)明显增高(P均<0.05);3组间腺瘤和息肉检出率无差异(P均>0.05);4 L-PEG+聚卡波非钙组袪泡评分优于2 L-PEG+聚卡波非钙组和4 L-PEG组(P<0.05);2 L-PEG+聚卡波非钙组耐受率明显高于4 L-PEG组(P=0.001);2 L-PEG+聚卡波非钙组再次接受意愿程度高于4 L-PEG+聚卡波非钙组和4 L-PEG组(P均<0.0125);2 L-PEG+聚卡波非钙组腹胀发生率明显低于4 L-PEG组和4 L-PEG+聚卡波非钙组(P<0.01);3组恶心、呕吐、腹痛、头晕、头痛比较差异均无统计学意义(P>0.05)。结论:PEG与聚卡波非钙联用比单用PEG肠道清洁效果好,2 L-PEG与聚卡波非钙联用不逊于4 L-PEG清肠效果,且耐受性更好,再接受意愿程度更高,不良反应事件较少。Objective:To explore the efficacy of calcium polycarbophil combined with polyethylene glycol electrolyte powder(PEG)in bowel preparation before colonoscopy.Methods:A total of 225 patients receiving colonoscopy at the Digestive Endoscopy Center of Shanghai Eighth People′s Hospital,from November 2021 to October 2022 were enrolled in the study.The patients were randomly divided into three groups:4 L-PEG group,2 L-PEG+calcium polycarbophil group and 4 L-PEG+calcium polycarbophil group,75 cases in each group.Aronchick score,Boston bowel preparation scale(BBPS)score,detection rate of polyps,adenomas and other lesions,antifoam effect score,patient tolerance rate,willingness to re-acceptance,and adverse reaction events were recorded and analysed.Results:Compared with 2 L-PEG+calcium polycarbophil group and 4 L-PEG group,Aroncheck score in 4 L-PEG+calcium polycarbophil group was significantly decreased(P<0.05),and total BBPS score,left half,middle and right half colon scores were significantly increased(all P<0.05).There was no difference in the detection rates of adenoma and polyp among the three groups(all P>0.05).The antifoam effect score of 4 L-PEG+calcium polycarbophil group was better than that of 2 L-PEG+calcium polycarbophil group and 4 L-PEG group(P<0.05).The tolerance rate of 2 L-PEG+calcium polycarbophil group was significantly higher than that of 4 L-PEG group(P=0.001).The proportion of re-acceptance willingness of 2 L-PEG+calcium polycarbophil group was higher than that of the other two groups(both P<0.0125).The proportion of abdominal distension in 2 L-PEG+calcium polycarbophil group was greatly lower than that in the other two groups(P<0.01).There were no significant differences in the comparison of nausea,vomiting,abdominal pain,dizziness and headache among 3 groups(P>0.05).Conclusion:The intestinal cleansing effect of calcium polycarbophil combined with PEG was more effective than that of PEG alone,the combination of 2 L-PEG and calcium polycarbophil had the similar intestinal cleansing effect as that o

关 键 词：结肠镜检查 肠道准备 复方聚乙二醇电解质散 聚卡波非钙 

分 类 号：R574.62[医药卫生—消化系统]