血清sTREM-1、HBP对口腔颌面肿瘤合并糖尿病患者术后感染的预测价值  

Predictive value of serum sTREM-1 and HBP on postoperative infection in cases with oral and maxillofacial tumors complicated with diabetes mellitus

作　　者：海丽达·马克西[1] 艾克热木·木沙[2] 杨芳[1] HAILIDA Makexi;AIKEREMU Musha;YANG Fang(Department of Outpatient,Cancer Hospital Affiliated to Xinjiang Medical University(Xinjiang Cancer Hospital),Urumqi,Xinjiang 830011,China;Department of Radiophysical Technology,Cancer Hospital Affiliated to Xinjiang Medical University(Xinjiang Cancer Hospital),Urumqi,Xinjiang 830011,China)

机构地区：[1]新疆医科大学附属肿瘤医院(新疆肿瘤医院)门诊部,新疆乌鲁木齐830011 [2]新疆医科大学附属肿瘤医院(新疆肿瘤医院)放射物理技术科,新疆乌鲁木齐830011

出　　处：《国际检验医学杂志》2024年第10期1180-1183,共4页International Journal of Laboratory Medicine

基　　金：新疆维吾尔自治区卫生与健康适宜技术推广项目(SYTG-2021142)。

摘　　要：目的 分析血清可溶性髓系细胞触发受体-1(sTREM-1)、肝素结合蛋白(HBP)对口腔颌面肿瘤合并糖尿病患者术后感染的预测价值。方法 选取2020年1月至2022年12月该院接受治疗的110例口腔颌面肿瘤合并糖尿病患者作为研究对象,按术后有无发生感染事件将患者分为未感染组(n=83)与感染组(n=27)。采用酶联免疫吸附试验检测口腔颌面肿瘤合并糖尿病患者术前血清sTREM-1、HBP水平。采用受试者工作特征(ROC)曲线评估血清sTREM-1、HBP水平对口腔颌面肿瘤合并糖尿病患者术后感染的预测价值;采用多因素Logistic回归分析探讨影响因素。结果 感染组sTREM-1、HBP水平高于未感染组,差异有统计学意义(P<0.05)。血清sTREM-1、HBP水平预测口腔颌面肿瘤合并糖尿病患者术后感染的曲线下面积(AUC)分别为0.707(95%CI:0.661~0.756)、0.885(95%CI:0.838~0.931),两者联合预测的AUC为0.931(95%CI:0.889~0.975)。感染组高血压例数、术中出血量、手术时间及住院时间明显高于未感染组,高级护理例数低于未感染组,差异有统计学意义(P<0.05)。多因素Logistic回归分析显示:住院时间≥14 d(OR=2.401,95%CI:1.331~4.332),sTREM-1>50.49 pg/mL(OR=3.494,95%CI:1.601~7.662),HBP>159.84 ng/L(OR=4.473,95%CI:1.819~10.997)是口腔颌面肿瘤合并糖尿病患者术后发生感染的影响因素(P<0.05)。结论 发生术后感染的口腔颌面肿瘤合并糖尿病患者的术前血清sTREM-1、HBP水平明显升高,血清sTREM-1、HBP水平升高是口腔颌面肿瘤合并糖尿病患者术后感染的影响因素,两者对辅助评估患者术后感染有一定临床价值。Objective To explore the predictive value of serum soluble myeloid cell trigger receptor-1(sTREM-1)and heparin-binding protein(HBP)on postoperative infection in cases with oral and maxillofacial tumors complicated with diabetes mellitus.Methods A total of 110 patients with oral and maxillofacial tumors complicated with diabetes mellitus treated in the hospital from January 2020 to December 2022 were selected as the study objects,and the patients were divided into uninfected group(n=83)and infected group(n=27)according to the occurrence of postoperative infection.Serum sTREM-1 and HBP levels in patients with oral and maxillofacial tumors diabetes mellitus before surgery were detected by enzyme-linked immunosorbent assay.Receiver operating characteristic(ROC)curve was used to evaluate the predictive value of serum sTREM-1 and HBP on postoperative infection in patients.The related factors of postoperative infection were investigated by multivariate Logistic regression.Results The levels of sTREM-1 and HBP in the infected group were higher compared with the uninfected group,and the differences were statistically significant(P<0.05).The area under the curve(AUC)of serum sTREM-1 and HBP levels in predicting postoperative infection was 0.707(95%CI:0.661-0.756)and 0.885(95%CI:0.838-0.931),respectively,and the AUC of the combined prediction was 0.931(95%CI:0.889-0.975).The number of patients with hypertension,intraoperative blood loss,operation time and hospital stay in infected group was higher compared with in non-infected group,and the number of advanced nursing was lower compared with the uninfected group,and the differences were statistically significant(P<0.05).Multivariate Logistic regression results showed that the length of hospitalization≥14 d(OR=2.401,95%CI:1.331-4.332),sTREM-1>50.49 pg/mL(OR=3.494,95%CI:1.601-7.662),HBP>159.84 ng/L(OR=4.473,95%CI:1.819-10.997)were the influential factors for postoperative infection(P<0.05).Conclusion Preoperative serum sTREM-1 and HBP levels are significantly increased in pa

关 键 词：口腔颌面肿瘤 糖尿病 可溶性髓系细胞触发受体-1 肝素结合蛋白 

分 类 号：R739.8[医药卫生—肿瘤]