N-杂环基酰胺类化合物的合成及其抑菌活性研究  

Synthesis and Fungicidal Activity of N-Heterocyclic Amide Compounds

作　　者：林迪 唐子龙 文御豪[1,2] 王娇芳 LIN Di;TANG Zi-long;WEN Yu-hao;WANG Jiao-fang(Key Laboratory of Theoretical Organic Chemistry and Functional Moleculeof Ministry of Education,Hunan University of Science and Technology,Xiangtan 411201,China;School of Chemistry and Chemical Engineering,Hunan University of Science and Technology,Xiangtan 411201,China)

机构地区：[1]湖南科技大学理论有机化学与功能分子教育部重点实验室,湖南湘潭411201 [2]湖南科技大学化学化工学院,湖南湘潭411201

出　　处：《精细化工中间体》2024年第2期21-24,37,共5页Fine Chemical Intermediates

基　　金：国家自然科学基金项目(22277025,21877034),湖南省自然科学基金项目(2022JJ30240),湖湘高层次人才聚集工程-创新团队(2021RC5028)。

摘　　要：2-氨基苯并噻唑及衍生物或2-氨基苯并咪唑与酰卤反应合成了一系列N-杂环基酰胺类化合物,并用1H NMR、13C NMR等对化合物结构进行了表征。同时采用生成速率法对这一类化合物进行了离体抑菌活性测试,大部分化合物都具有良好的抑菌活性。化合物3b对所测试6种病菌的抑制活性均为100%;化合物3a对5种病菌的抑制活性也都为100%;化合物3g、3l和3r对稻瘟病菌、菌核病菌和纹枯病菌的抑制活性也都为100%。A series of N-heterocyclic amide compounds were synthesized through the reaction of 2-aminobenzothiazole and its derivatives or 2-aminobenzimidazole with acyl halides,and their structures were characterized by 1H NMR and 13C NMR.At the same time,the in vitro fungicidal activity of these compounds was tested by the formation rate method,and most of the compounds had good fungicidal activity.The activity of compound 3b against the six tested pathogens was 100%.Compound 3a also showed 100%inhibitory activity against five pathogens.The inhibitory activities of compounds 3g,3l and 3r against Magnaporthe oryzae,Sclerotinia sclerotiorum and Rhizoctonia solani were also 100%.

关 键 词：酰胺 N-杂环基酰胺 2-氨基苯并噻唑 合成 抑菌活性 

分 类 号：TQ455[化学工程—农药化工]