Muscle strength deficits are associated with low bone mineral density in young pediatric cancer survivors:The iBoneFIT project  

作　　者：Andres Marmol-Perez Jose J.Gil-Cosano Esther Ubago-Guisado Francisco J.Llorente-Cantarero Juan Francisco Pascual-Gázquez Kirsten K.Ness Vicente Martinez-Vizcaino Jonatan R.Ruiz Luis Gracia-Marco 

机构地区：[1]Department of Physical Education and Sports,Faculty of Sport Sciences,Sport and Health University Research Institute(iMUDS),University of Granada,Granada 18011,Spain [2]Department of Epidemiology and Cancer Control,St.Jude Children's Research Hospital,Memphis,TN 38105,USA [3]Department of Communication and Education,Loyola University Andalusia,Seville 41704,Spain [4]Biosanitary Research Institute,ibs.Granada,Granada 18012,Spain [5]Maimonides Biomedical Research Institute of Cordoba(IMIBIC),Cordoba 14004,Spain [6]CIBEROBN,Biomedical Research Networking Center for Physiopathology of Obesity and Nutrition,Carlos III Health Institute,Madrid 28029,Spain [7]Department of Specific Didactics,Faculty of Education,University of Cordoba,Cordoba 14071,Spain [8]Pediatric and adolescent hematology and oncology service,Pediatrics and Pediatric Surgery Clinical Management Unit,Virgen de las Nieves University Hospital,Granada 18014,Spain [9]Health and Social Research Center,Universidad de Castilla-La Mancha,Cuenca 13001,Spain

出　　处：《Journal of Sport and Health Science》2024年第3期419-427,共9页运动与健康科学（英文）

基　　金：support by the Spanish Ministry of Science and Innovation(Ref:PID2020-117302RA-I00);La Caixa Foundation(Ref:LCF/BQ/PR19/11700007);the University of Granada Plan Propio de Investigación 2021-Excellence actions:Unit of Excellence on Exercise,Nutrition,and Health(UCEENS)and by CIBEROBN,Centro de Investigación Biomédica en Red(CB22/3/00058);Instituto de Salud Carlos III,Ministerio de Ciencia e Innovación and Unión Europea-European Regional Development Fund;AMP was also recipient of a predoctoral fellowship(FPU20/05530)by the Spanish Ministry of Education,Culture and Sport;EUG was supported by the Maria Zambrano fellowship by the Ministerio de Universidades y la Unión Europea-NextGenerationEU.

摘　　要：Background Pediatric cancer survivors are at increased risk of muscle weakness and low areal bone mineral density(aBMD).However,the prevalence of muscle strength deficits is not well documented,and the associations of muscle strength with aBMD are unknown in this population.Therefore,this study aimed to investigate the prevalence of upper-and lower-body muscle strength deficits and to examine the associations of upper-and lower-body muscle strength with age-,sex,and race-specific aBMD Z-scores at the total body,total hip,femoral neck,and lumbar spine.Methods This cross-sectional study included 116 pediatric cancer survivors(12.1±3.3 years old,mean±SD;42.2%female).Upper-and lower-body muscle strength were assessed by handgrip and standing long jump test,respectively.Dual‑energy X‑ray absorptiometry was used to measure aBMD(g/cm2).Associations between muscle strength and aBMD were evaluated in multivariable linear regression models.Logistic regression was used to evaluate the contribution of muscle strength(1-decile lower)to the odds of having low aBMD(Z-score≤1.0).All analyses were adjusted for time from treatment completion,radiotherapy exposure,and body mass index.Results More than one-half of survivors were within the 2 lowest deciles for upper-(56.9%)and lower-body muscle strength(60.0%)in comparison to age-and sex-specific reference values.Muscle strength deficits were associated with lower aBMD Z-scores at all sites(B=0.133–0.258,p=0.001–0.032).Each 1-decile lower in upper-body muscle strength was associated with 30%–95%higher odds of having low aBMD Z-scores at all sites.Each 1-decile lower in lower-body muscle strength was associated with 35%–70%higher odds of having low aBMD Z-scores at total body,total hip,and femoral neck.Conclusion Muscle strength deficits are prevalent in young pediatric cancer survivors,and such deficits are associated with lower aBMD Z-scores at all sites.These results suggest that interventions designed to improve muscle strength in this vulnerable population may ha

关 键 词：Bone health Childhood cancer DXA Lean mass Resistance training 

分 类 号：R73[医药卫生—肿瘤]