CC及CXC趋化因子在流感病毒感染过程中调控不同免疫细胞的作用研究进展  

Research progress on the role of CC and CXC chemokines in regulating di-fferent immune cells during influenza virus infection

作　　者：王文静 张善语[1] 王晓龙 WANG Wen-jing;ZHANG Shan-yu;WANG Xiao-long(College of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Experimental Center,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Key Laboratory of Classical Theory of Traditional Chinese Medicine,Ministry of Education,Jinan 250355,China;Shandong Key Laboratory of Basic Research of Traditional Chinese Medicine,Jinan 250355,China)

机构地区：[1]山东中医药大学药学院,山东济南250355 [2]山东中医药大学实验中心,山东济南250355 [3]教育部中医药经典理论重点实验室,山东济南250355 [4]山东省中医药基础研究重点实验室,山东济南250355

出　　处：《中国感染控制杂志》2024年第5期638-645,共8页Chinese Journal of Infection Control

基　　金：国家自然科学基金项目(82003715);山东省自然科学基金项目(ZR2021LZY017)。

摘　　要：流行性感冒(简称流感)是由流感病毒感染引起的急性呼吸道传染病。流感病毒经呼吸道侵袭人体后,呼吸道上皮细胞首先作出反应,产生多种细胞因子诱导机体发挥免疫应答,其中CC趋化因子及CXC趋化因子在流感病毒感染过程中调控多种免疫细胞,在流感病毒感染早期控制炎症反应,维持机体稳态过程中发挥重要作用。分析宿主体内趋化因子调控免疫细胞在流感病毒感染过程中的作用机制,从而为治疗流感提供新的策略。本文主要针对流感病毒感染过程中发挥主要作用的CC趋化因子、CXC趋化因子及其相关受体对各类型免疫细胞的调节作用进行综述。Influenza is an acute respiratory infectious disease caused by influenza virus infection.After influenza virus invades the human body through the respiratory tract,the epithelial cells of the respiratory tract react first and produce a variety of cytokines to induce immune responses of human body.CC chemokines and CXC chemokines regulate a variety of immune cells in the process of influenza virus infection,and play important roles in the control of inflammatory response and maintenance of homeostasis in human body at the early stage of influenza virus infection.Analyzing the role of chemokines in regulating immune cells in host’s body during the process of influenza virus infection can provide new strategies for treating against influenza.In this paper,the regulatory effects on various types of immune cells by CC and CXC chemokines as well as their related receptors during influenza virus infection are reviewed.

关 键 词：流行性感冒 CC型趋化因子 CXC型趋化因子 趋化因子受体 免疫细胞 

分 类 号：R392[医药卫生—免疫学] R511.7[医药卫生—基础医学]