乳腺癌患者病理特征与Bcl-2、CXCL13、PAX8表达情况的关系分析  

Analysis of relationship between pathological features and expression of Bcl-2,CXCL13 and PAX8 in patients with breast cancer

作　　者：王洋[1] 刘伟 韩晓东 马娜 秦蕊 WANG Yang;LIU Wei;HAN Xiaodong;MA Na;QIN Rui(the third Department of Breast,Tangshan Workers′Hospital,Tangshan,Hebei 063000,China;Department of Outpatient and Emergency,Tangshan Workers′Hospital,Tangshan,Hebei 063000,China;Department of Traditional Chinese Medicine,Tangshan Workers′Hospital,Tangshan,Hebei 063000,China;the third Department of Orthopedic Surgery,Tangshan Workers′Hospital,Tangshan,Hebei 063000,China)

机构地区：[1]河北省唐山市人民医院乳腺三科,河北唐山063000 [2]河北省唐山市人民医院门急诊事业部,河北唐山063000 [3]河北省唐山市人民医院中医科,河北唐山063000 [4]河北省唐山市人民医院骨外三科,河北唐山063000

出　　处：《检验医学与临床》2024年第10期1431-1435,共5页Laboratory Medicine and Clinic

基　　金：2022年度河北省中医药管理局科研计划项目(2022571)。

摘　　要：目的分析乳腺癌患者病理特征与B细胞淋巴瘤/白血病-2基因(Bcl-2)、趋化因子配体13(CXCL13)、配对盒基因8抗体(PAX8)表达情况的关系。方法收集2021年1月至2023年1月该院收治的160例乳腺癌患者临床资料。采用免疫组化法对其癌组织与癌旁组织Bcl-2、CXCL13、PAX8表达情况进行检测,并分析3项指标与患者病理特征的关系。结果与癌旁组织比较,癌组织Bcl-2、CXCL13、PAX8阳性率更高,差异有统计学意义(P<0.05)。与雌激素受体(ER)阴性、肿瘤最大径≥3 cm、孕激素受体(PR)阴性患者比较,ER阳性、肿瘤最大径<3 cm、PR阳性患者中Bcl-2高表达占比更高,差异有统计学意义(P<0.05);与无淋巴结转移、Ⅰ~Ⅱ期患者比较,淋巴结转移、Ⅲ~Ⅳ期患者中CXCL13高表达占比更高,差异有统计学意义(P<0.05);与Ⅰ~Ⅱ期、高/中分化、无淋巴结转移患者比较,Ⅲ~Ⅳ期、低分化、有淋巴结转移患者中PAX8高表达占比更高,差异有统计学意义(P<0.05)。ER、PR表达情况与Bcl-2表达情况呈正相关(P<0.05),肿瘤最大径与Bcl-2表达情况呈负相关(P<0.05);临床分期、淋巴结转移情况与CXCL13、PAX8表达情况呈正相关(P<0.05);分化程度与PAX8表达情况呈负相关(P<0.05)。结论乳腺癌患者Bcl-2、CXCL13、PAX8表达情况对疾病的发生和发展具有明显影响,有望成为评估乳腺癌患者病情严重程度的标志物。Objective To analyze the relationship between pathological features of breast cancer patients and the expression status of B-cell lymphoma/leukemia-2 gene(Bcl-2),chemokine ligand 13(CXCL13)and paired-box gene 8 antibody(PAX8).Methods The clinical data of 160 breast cancer patients admitted to Tangshan Workers′Hospital from January 2021 to January 2023 were collected.The expression status of Bcl-2,CXCL13 and PAX8 in cancer tissues and adjacent tissues were detected by immunohistochemical method,and the relationship between the three indicators and the pathological characteristics of patients was analyzed.Results The positive rates of Bcl-2,CXCL13 and PAX8 in cancer tissues were higher than those in paraneoplastic tissue(P<0.05).Compared patients with negative estrogen receptor(ER),tumor diameter≥3 cm,negative progesterone receptor(PR),patients with positive ER patients,tumor diameter<3 cm,positive PR had a higher proportion of Bcl-2 high expression(P<0.05).Compared with patients with no lymph node metastasis and stageⅠ-stageⅡ,the proportion of patients with high CXCL13 expression was higher in patients with lymph node metastasis and stageⅢto stageⅣ(P<0.05).Compared with patients with stageⅠ-stageⅡ,highly/moderately differentiated and no lymph node metastasis,patients with stageⅢto stageⅣ,poorly differentiated and lymph node metastasis had a higher proportion of high PAX8 expression(P<0.05).The expression status of ER and PR correlated positively with the expression status of Bcl-2(P<0.05),and the tumor diameter correlated negatively with the expression status of Bcl-2(P<0.05).The expression status of CXCL13 and PAX8 correlated positively with clinical stage and status of lymph node metastasis(P<0.05).The degree of differentiation correlated negatively with PAX8 expression status(P<0.05).Conclusion The expression status of Bcl-2,CXCL13 and PAX8 had a significant impact on the disease certification and development of breast cancer,and which are expected to be markers to evaluate the severity of b

关 键 词：乳腺癌 B细胞淋巴瘤/白血病-2 趋化因子配体13 配对盒基因8抗体 临床病理 

分 类 号：R737.9[医药卫生—肿瘤]