阿尔茨海默病患者认知功能与外周血炎症因子的相关性  

Correlation between cognitive function and peripheral blood inflammatory factors in patients with Alzheimer's disease

作　　者：杨应环 陈思路 胡小勇[1] 蒋颖 沙蓉 YANG Ying-huan;CHEN Si-lu;HU Xiao-yong;JIANG Ying;SHA Rong(Department of Geriatrics,Mental Health Center Affiliated to East China Normal University,Shanghai 200335,CHINA;Department of Psychiatry,Mental Health Center Affiliated to East China Normal University,Shanghai 200335,CHINA)

机构地区：[1]华东师范大学附属精神卫生中心老年科,上海200335 [2]华东师范大学附属精神卫生中心精神科,上海200335

出　　处：《海南医学》2024年第10期1396-1399,共4页Hainan Medical Journal

基　　金：上海市长宁区精神卫生中心院级科研项目(编号:202111)。

摘　　要：目的分析阿尔茨海默病(AD)患者认知功能与外周血炎症因子的相关性。方法回顾性选取2019年1月至2023年1月华东师范大学附属精神卫生中心收治的120例AD患者作为AD组,同期选取年龄、性别相匹配的40例健康体检志愿者作为健康组。比较两组受检者的简易精神状态量表(MMSE)评分、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)水平。根据临床痴呆评定量表(CDR)评分将120例AD患者分为轻度组(CDR评分1分)39例、中度组(CDR评分2分)41例和重度组(CDR评分3分)40例,比较不同痴呆程度AD患者的MMSE评分、IL-6、TNF-α、CRP水平,采用Pearson相关性分析外周血IL-6、TNF-α、CRP水平与MMSE、CDR评分的相关性。结果AD组患者的MMSE评分为(15.12±7.26)分,明显低于健康组的(28.55±0.41)分,外周血IL-6、TNF-α水平分别为(7.06±1.22)pg/mL、(8.96±1.08)pg/mL,明显高于健康组的(3.64±0.36)pg/mL、(6.22±0.69)pg/mL,差异均有统计学意义(P<0.05),AD组患者的外周血CRP水平为(3.35±0.76)mg/L,略高于健康组的(3.13±0.45)mg/L,但差异无统计学意义(P>0.05);轻度组患者的MMSE评分为(24.16±1.13)分,明显高于中度组的(15.08±1.55)分和重度组的(6.34±1.02)分,中度组的MMSE评分明显高于重度组,差异均有统计学意义(P<0.05);轻度组患者的外周血IL-6、TNF-α水平分别为(3.99±0.41)pg/mL、(6.91±0.98)pg/mL,明显低于中度组的(5.91±0.58)pg/mL、(8.56±0.82)pg/mL和重度组的(11.24±1.29)pg/mL、(11.37±1.31)pg/mL,中度组的外周血IL-6、TNF-α水平明显低于重度组,差异均有统计学意义(P<0.05),轻度组患者的外周血CRP水平为(3.18±0.49)mg/L,略低于中度组的(3.25±0.52)mg/L和重度组的(3.62±1.53)mg/L,但三组患者外周血CRP水平比较差异无统计学意义(P>0.05);Pearson相关性分析结果显示,外周血IL-6、TNF-α水平与MMSE评分均呈负相关(P<0.05),与CDR评分呈正相关(P<0.05);外周血CRP水平与MMSE评分、CDR评分均无Objective To analyze the correlation between cognitive function and peripheral blood inflammato-ry factors in patients with Alzheimer's disease(AD).Methods A total of 120 patients with AD in Mental Health Center Affiliated to East China Normal University were retrospectively selected between January 2019 and January 2023 as AD group,and 40 healthy volunteers with matched age and gender who received physical examination were selected as healthy group.The score of Mini-mental State Examination(MMSE)and levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and C-reactive protein(CRP)were compared between the two groups.According to the Clinical De-mentia Rating(CDR),120 AD patients were divided into mild group(CDR score of 1 point,39 cases),moderate group(CDR score of 2 points,41 cases),and severe group(CDR score of 3 points,40 cases).The MMSE score and levels of IL-6,TNF-α,and CRP were compared among AD patients with different dementia degrees.Pearson correlation analysis was used to analyze the correlation of levels of peripheral blood IL-6,TNF-αand CRP with MMSE score and CDR score.Results The MMSE score of patients in AD group was(15.12±7.26)points,significantly lower than(28.55±0.41)points in healthy group(P<0.05);the levels of peripheral blood IL-6 and TNF-αwere(7.06±1.22)pg/mL and(8.96±1.08)pg/mL,significantly higher than(3.64±0.36)pg/mL and(6.22±0.69)pg/mL in healthy group(P<0.05).The peripheral blood CRP level was slightly higher than that in healthy group:(3.35±0.76)mg/L vs(3.13±0.45)mg/L,P>0.05.The MMSE score in mild group with(24.16±1.13)points was significantly higher than(15.08±1.55)points in mod-erate group and(6.34±1.02)points in severe group,and the score was significantly higher in moderate group than severe group(P<0.05).The peripheral blood IL-6 and TNF-αwith(3.99±0.41)pg/mL and(6.91±0.98)pg/mL in mild group were significantly lower than(5.91±0.58)pg/mL and(8.56±0.82)pg/mL in moderate group and(11.24±1.29)pg/mL and(11.37±1.31)pg/mL in severe group,and the levels in pe

关 键 词：阿尔茨海默病 认知功能 简易精神状态量表 白细胞介素-6 肿瘤坏死因子-Α C反应蛋白 

分 类 号：R749[医药卫生—神经病学与精神病学]