急性脑梗死介入治疗联合静脉溶栓治疗的效果观察  

Observation on the effect of interventional therapy combined with intravenous thrombolysis for acute cerebral infarction

作　　者：宁方波[1] 赵大鹏[1] 王琳[2] 黄化云[1] NING Fang-bo;ZHAO Da-peng;WANG Lin(Department of vertigo and Dementia,Tai'an Central Hospital,Tai'an 271000,China)

机构地区：[1]泰安市中心医院眩晕失智科,271000 [2]泰安市中心医院介入诊疗科,271000

出　　处：《中国实用医药》2024年第9期77-80,共4页China Practical Medicine

摘　　要：目的 探究介入治疗联合静脉溶栓对急性脑梗死患者的治疗效果。方法 80例急性脑梗死患者,合理且随机划分为对照组和观察组,每组40例。对照组采取静脉溶栓治疗,观察组在对照组基础上采用介入治疗。比较两组患者神经功能缺损评分、血清学相关指标(神经生长因子、神经元特异性烯醇化酶、脑钠肽)、活化部分凝血活酶时间、凝血酶原时间、凝血酶时间、纤维蛋白原、并发症发生情况。结果 观察组患者治疗后1 d、7 d、2周神经功能缺损评分均低于对照组(P<0.05)。治疗后,两组患者神经生长因子、神经元特异性烯醇化酶、脑钠肽水平均下降,且观察组患者神经生长因子(95.31±9.65)ng/ml、神经元特异性烯醇化酶(10.26±1.37)μg/L、脑钠肽(157.43±13.25)ng/L均低于对照组的(116.38±10.46)ng/ml、(15.86±1.86)μg/L、(189.46±17.78)ng/L(P<0.05)。治疗后,观察组患者活化部分凝血活酶时间(35.43±2.21)s、凝血酶原时间(13.26±1.53)s、凝血酶时间(17.46±2.24)s比对照组的(30.48±2.15)、(10.93±1.29)、(15.55±1.87)s更长,纤维蛋白原(2.44±0.43)g/L比对照组的(4.21±0.64)g/L更低(P<0.05)。观察组并发症发生率5.00%比对照组的25.00%更低(P<0.05)。结论 针对急性脑梗死患者,采取静脉溶栓联合介入治疗可有效改善患者神经功能及血清学状况,且可以有效改善活化部分凝血活酶时间等相关临床指标,减少相关并发症的发生,该治疗方案临床应用效果理想,预后效果良好,值得在临床广泛推广。Objective To explore the effect of interventional therapy combined with intravenous thrombolysis for patients with acute cerebral infarction.Methods 80 patients with acute cerebral infarction were randomly divided into a control group and an observation group,with 40 cases in each group.The control group received intravenous thrombolysis,and the observation group received interventional therapy on the basis of the control group.Patients in both groups were compared in terms of neurological deficit score,serological related indexes(nerve growth factor,neuron-specific enolase,brain natriuretic peptide),activated partial thromboplastin time,prothrombin time,thrombin time,fibrinogen,and complications.Results The neurological deficit scores of the observation group at 1,7 and 2 d after treatment were lower than those of the control group(P<0.05).After treatment,the levels of nerve growth factor,neuron-specific enolase and brain natriuretic peptide decreased in both groups;the observation group had nerve growth factor of(95.31±9.65)ng/ml,neuron-specific enolase of(10.26±1.37)μg/L and brain natriuretic peptide of(157.43±13.25)ng/L,which were lower than(116.38±10.46)ng/ml,(15.86±1.86)μg/L and(189.46±17.78)ng/L in the control group(P<0.05).After treatment,the observation group had activated partial thromboplastin time of(35.43±2.21)s,prothrombin time of(13.26±1.53)s and thrombin time of(17.46±2.24)s,which were longer than(30.48±2.15),(10.93±1.29)and(15.55±1.87)s in the control group;the observation group had lower fibrinogen of(2.44±0.43)g/L than(4.21±0.64)g/L in the control group(P<0.05).The complication rate of 5.00%in the observation group was lower than 25.00%in the control group(P<0.05).Conclusion For patients with acute cerebral infarction,intravenous thrombolysis combined with interventional therapy can effectively improve the neurological function and serological status of patients,and can effectively improve the relevant clinical indicators such as activated partial thromboplastin time,and reduce

关 键 词：静脉溶栓 介入治疗 急性脑梗死 神经功能 

分 类 号：R743.33[医药卫生—神经病学与精神病学]