儿科双相障碍的临床研究进展  

Progress in clinical research of pediatric bipolar disorder

作　　者：刘韬 陈天铭 冯梓航 王欢 LIU Tao;CHEN Tianming;FENG Zihang;WANG Huan(Department of School of Nursing,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100000,China)

机构地区：[1]中国医学科学院北京协和医学院护理学院,北京100000

出　　处：《中国当代医药》2024年第13期185-189,共5页China Modern Medicine

摘　　要：双相障碍是一种具有复杂病程和多重影响因素的精神疾病,可由生物化学、神经内分泌、神经免疫、大脑结构异常、遗传、心理社会环境等多种因素引起,其发作性、循环往复性、混合迁徙性、潮起潮落式病程不一而足,其发病时会有冲动行为和攻击行为,造成自伤或伤人等后果,此类行为将对患者的生活及社会功能造成严重影响,同时也将对后续治疗造成诸多不便。本文归纳总结了现有的相关文献,系统回顾了儿科双相障碍的临床表现和病程,以及其涉及遗传、环境和心理社会因素的多方面影响。同时,本文详细阐述了对于此类疾病现有的诊断标准和工具,以及药物治疗、心理治疗和生活方式干预在治疗双相障碍中的综合应用。此外,针对双相障碍患者的后代,本文探讨了对其进行风险评估以及对前驱症状的关注等的重要性。本文还展望了未来双相障碍研究领域的挑战和机遇,以期为临床实践和科学研究提供有益的指导。Bipolar disorder is a mental disease with complex course and multiple influencing factors.It can be caused by biochemical,neuroendocrine,neuroimmune,brain structural abnormalities,heredity,psychosocial environment and other factors.Its episodic,circulatory,mixed and ebb and flow course varies,and its onset will involve impulsive and aggressive behavior.Such behavior will have a serious impact on the patient's life and social function,and will also cause a lot of inconvenience for subsequent treatment.This article summarizes the existing literature and systematically reviews the clinical manifestations and course of pediatric bipolar disorder,as well as the multifaceted influences of genetic,environmental and psychosocial factors.At the same time,the present diagnostic criteria and tools for this disorder are described in detail,as well as the integrated application of medication,psychotherapy,and lifestyle intervention in the treatment of bipolar disorder.In addition,this paper discusses the importance of risk assessment and attention to prodromal symptoms for offspring of people with bipolar disorder.The paper also looks forward to the challenges and opportunities in the field of bipolar disorder research in the future,with a view to providing useful guidance for clinical practice and scientific research.

关 键 词：儿科双相情感障碍 临床表现 病程 前驱症状 高危后代 

分 类 号：R749.4[医药卫生—神经病学与精神病学]