精神分裂症患者不同阶段血清IL-1β、IL-16水平与阴性症状相关性研究  

Correlation between serum IL-1β,IL-16 levels and negative symptoms in different stages of schizophrenia

作　　者：王安珍 张许来 严凡凡 裴文志 程夏龙 Wang Anzhen;Zhang Xulai;Yan Fanfan;Pei Wenzhi;Cheng Xialong(Dept of Anxiety and Depression,Affiliated Psychological Hospital of Anhui Medical University,Anhui Mental Health Center,Hefei Fourth People′s Hospital,Anhui Clinical Research Center for Mental Disorders,Hefei 230031;Dept of Geriatric Psychiatry,Affiliated Psychological Hospital of Anhui Medical University,Anhui Mental Health Center,Hefei Fourth People′s Hospital,Anhui Clinical Research Center for Mental Disorders,Hefei 230031;Dept of General Psychiatry,Affiliated Psychological Hospital of Anhui Medical University,Anhui Mental Health Center,Hefei Fourth People′s Hospital,Anhui Clinical Research Center for Mental Disorders,Hefei 230031)

机构地区：[1]安徽医科大学附属心理医院,安徽省精神卫生中心,合肥市第四人民医院,安徽省精神心理疾病临床研究中心焦虑抑郁科,合肥230031 [2]安徽医科大学附属心理医院,安徽省精神卫生中心,合肥市第四人民医院,安徽省精神心理疾病临床研究中心老年心理科,合肥230031 [3]安徽医科大学附属心理医院,安徽省精神卫生中心,合肥市第四人民医院,安徽省精神心理疾病临床研究中心普通精神科,合肥230031

出　　处：《安徽医科大学学报》2024年第4期703-708,共6页Acta Universitatis Medicinalis Anhui

基　　金：安徽省重点研究和开发计划项目(编号:201904a07020009)。

摘　　要：目的探究首发精神分裂症患者、复发精神分裂症患者和健康人群血清炎症因子的差异性以及精神分裂症患者血清炎症因子与阴性症状的相关性,为临床干预提供参考依据。方法该研究共纳入就诊的首发精神分裂症患者86例(首发组)、复发精神分裂症患者80例(复发组)和健康对照人群82例(对照组),分析三组间血清炎症因子的差异性及患者组(首发组、复发组)血清炎症因子与阴性症状的相关性。结果三组间血清白细胞介素(IL)-1β水平、IL-16比较差异有统计学意义(P<0.05)。两组间比较首发组血清IL-1β明显高于复发组和对照组(P<0.05),首发组和复发组血清IL-16明显高于对照组(P<0.05)。首发组血清IL-1β与阳性和阴性症状量表(PANSS)中一般精神病理量表因子分呈负相关(P<0.05),复发组血清IL-16与PANSS量表的阴性症状量表因子分呈正相关(P<0.05)。IL-16水平可能是影响首发组和复发组发病的独立危险因素(P<0.05)。结论精神分裂症患者与健康人群血清IL-1β、IL-16水平存在差异。复发精神分裂症患者血清IL-16水平与阴性症状存在相关性。IL-16水平可能是影响精神分裂症发病的独立危险因素。Objective To explore the difference of serum inflammatory factors in patients with first episode schizophrenia,patients with relapse episode schizophrenia and healthy people,and the correlation between serum inflammatory factors with negative symptoms in patients with schizophrenia,so as to provide reference for clinical intervention.Methods A total of 86 patients with first episode schizophrenia(first episode group),80 patients with relapse episode schizophrenia(relapse episode group)and 82 healthy people(control group)were included in the study.The difference of serum inflammatory factors among the three groups and the correlation between serum inflammatory factors with negative symptoms were analyzed.Results There were significant differences in serum interleukin(IL)-1βand IL-16 levels among the three groups(P<0.05).The analysis and comparison between the two groups showed that the serum IL-1βin first episode group was significantly higher than that in relapse episode group and control group(P<0.05),serum IL-16 in first episode group and relapse episode group was significantly higher than that in control group(P<0.05).Serum IL-1βwas negatively correlated with PANSS general psychopathological scale factor score in first episode group(P<0.05),and serum IL-16 was positively correlated with PANSS negative symptom scale factor score in relapse episode group(P<0.05).IL-16 level might be an independent risk factor affecting the onset of first episode group and relapse episode group(P<0.05).Conclusion There are differences in serum levels of IL-1βand IL-16 between patients with schizophrenia and healthy people.Serum IL-16 levels in patients with relapse episode schizophrenia are associated with negative symptoms.IL-16 level may be an independent risk factor for schizophrenia.

关 键 词：精神分裂症 白介素-1Β 白介素-16 阴性症状 

分 类 号：R749.3[医药卫生—神经病学与精神病学]