奥美拉唑联合纤维蛋白粘合剂在消化性溃疡出血中的应用效果分析  

Clinical Efficacy of Omeprazole Combined with Fibrin Adhesive in the Treatment of Peptic Ulcer Bleeding

作　　者：黄莉莉 黄晶晶 HUANG Lili;HUANG Jingjing(Pharmacy Department,Xinyang Third People’s Hospital,Xinyang,Henan 464000,China;Department of Gastroenterology,Xinyang Third People’s Hospital,Xinyang,Henan 464000,China)

机构地区：[1]信阳市第三人民医院药剂科,河南信阳464000 [2]信阳市第三人民医院消化内科,河南信阳464000

出　　处：《中国烧伤创疡杂志》2024年第3期240-244,共5页The Chinese Journal of Burns Wounds & Surface Ulcers

摘　　要：目的探讨奥美拉唑联合纤维蛋白粘合剂在消化性溃疡出血中的应用效果。方法选取2020年5月至2022年5月信阳市第三人民医院收治的86例消化性溃疡出血患者作为研究对象,按照不同治疗方法将其分为联合组(43例)和单一组(43例),联合组患者在对症支持治疗的基础上采用奥美拉唑联合纤维蛋白粘合剂治疗,单一组患者在对症支持治疗的基础上单纯采用奥美拉唑治疗,对比观察两组患者血清谷胱甘肽过氧化物酶(GSH-Px)、脂质过氧化物(LPO)水平,胃组织内H^(+)-K^(+)-ATP酶活性及胃液酸碱度、凝血功能与临床疗效。结果治疗7 d后,联合组患者血清GSH-Px水平、胃液酸碱度均明显高于单一组(t=3315、2238,P=0001、0028),血清LPO水平、胃组织内H^(+)-K^(+)-ATP酶活性均明显低于单一组(t=3279、2651,P=0002、0010)。治疗2、7 d后,联合组患者凝血酶原时间、凝血酶时间、活化部分凝血活酶时间均明显短于单一组(治疗2 d后:t=2186、2250、2061,P=0032、0027、0042;治疗7 d后:t=2090、2003、2558,P=0040、0048、0012),纤维蛋白原水平均明显高于单一组(t=2199、2352,P=0031、0021)。联合组患者总有效率为9535%,明显高于单一组患者的总有效率8140%(χ^(2)=4074,P=0044)。结论与单纯应用奥美拉唑相比,奥美拉唑联合纤维蛋白粘合剂更能有效调节消化性溃疡出血患者GSH-Px、LPO水平,改善H^(+)-K^(+)-ATP酶活性、胃液酸碱度和凝血功能,治疗效果更好,临床应用价值更高。Objective To study the clinical efficacy of omeprazole combined with fibrin adhesive in the treatment of peptic ulcer bleeding.Methods 86 patients with peptic ulcer bleeding,admitted to Xinyang Third People’s Hospital from May 2020 to May 2022 were enrolled as the research subjects and divided,according to the different treatments,into the combination group(n=43)and the single group(n=43).Patients in the combination group were treated with omeprazole combined with fibrin adhesive based on symptomatic and supportive treatments,whereas patients in the single group were treated with omeprazole alone based on symptomatic and supportive treatments.The levels of serum glutathione peroxidase(GSH-Px)and lipid hydroperoxide(LPO),the activity of H^(+)-K^(+)-ATPase in gastric tissues,the pH value of gastric juice,coagulation function and clinical efficacy were compared between the two groups.Results After 7 days of treatment,the serum GSH-Px level and pH value of gastric juice in the combination group were significantly higher than those in the single group(t=3315 and 2238,P=0001 and 0028),and the serum LPO level and H^(+)-K^(+)-ATPase activity in gastric tissues were significantly lower in the combination group(t=3279 and 2651,P=0002 and 0010).After 2 and 7 days of treatment,the prothrombin time,thrombin time,and activated partial thromboplastin time of patients in the combination group were all significantly shorter than those in the single group(after 2 days:t=2186,2250 and 2061,P=0032,0027 and 0042;after 7 days:t=2090,2003 and 2558,P=0040,0048 and 0012),and the fibrinogen level was significantly higher in the combination group(t=2199 and 2352,P=0031 and 0021).The total effective rate was 9535%in the combination group,being remarkably higher than 8140%in the single group(χ^(2)=4074,P=0044).Conclusion Compared with the simple application of omeprazole,the combined application of omeprazole and fibrin adhesive is more effective in regulating GSH-Px and LPO levels,improving H^(+)-K^(+)-ATPase activity,pH value of gastric

关 键 词：消化性溃疡 出血 纤维蛋白粘合剂 奥美拉唑 谷胱甘肽过氧化物酶 脂质过氧化物 凝血功能 

分 类 号：R573.1[医药卫生—消化系统]