银杏叶提取物在外伤性鼓膜大穿孔中的应用效果分析  

Clinical Efficacy of Ginkgo Biloba Extract in the Treatment of Traumatic Tympanic Membrane Perforation

作　　者：黄莹[1] 蔡洁[2] 李波蓬 刘艳[2] 丁锋[2] HUANG Ying;CAI Jie;LI Bopeng;LIU Yan;DING Feng(Department of Pharmacy,Wuhan Hankou Hospital,Wuhan,Hubei 430012,China;ENT Department,Wuhan Hankou Hospital,Wuhan,Hubei 430012,China)

机构地区：[1]武汉市汉口医院药学部,湖北武汉430012 [2]武汉市汉口医院耳鼻咽喉科,湖北武汉430012

出　　处：《中国烧伤创疡杂志》2024年第3期249-252,共4页The Chinese Journal of Burns Wounds & Surface Ulcers

基　　金：武汉市卫生健康委员会基金项目(WZ20C34)。

摘　　要：目的探讨银杏叶提取物在外伤性鼓膜大穿孔中的应用效果。方法选取2018年1月至2022年12月武汉市汉口医院收治的86例外伤性鼓膜大穿孔患者作为研究对象,按照不同治疗方法将其分为观察组(43例)和对照组(43例),观察组患者采用湿润烧伤膏棉片贴补联合银杏叶提取物注射液治疗,对照组患者单纯采用湿润烧伤膏棉片贴补治疗,对比观察两组患者鼓膜穿孔愈合率和愈合时间以及听力改善情况与药物不良反应发生情况。结果治疗14 d后,观察组患者鼓膜穿孔愈合率为9302%,与对照组患者的鼓膜穿孔愈合率9070%无明显差异(χ^(2)=0156,P=0693)。观察组患者鼓膜穿孔愈合时间为(109±26)d,与对照组患者的鼓膜穿孔愈合时间(116±29)d无明显差异(t=1179,P=0242)。治疗结束后,观察组患者听力改善总有效率为9535%,明显高于对照组患者的听力改善总有效率7674%(χ^(2)=6198,P=0013)。治疗期间,两组患者均未发生药物不良反应。结论银杏叶提取物虽不能提高外伤性鼓膜大穿孔愈合率,但可改善听力下降等症状,且不会引发明显不良反应,值得临床推广应用。Objective To study the clinical efficacy of ginkgo biloba extract in the treatment of traumatic tympanic membrane perforation.Methods 86 patients with traumatic tympanic membrane perforation,admitted to Wuhan Hankou Hospital between January 2018 and December 2022,were enrolled as research subjects and divided,based on the treat-ments they received,into the study group(n=43)and the control group(n=43).Patients in the study group were treated with MEBO-impregnated cotton patch combined with injection of ginkgo biloba extract,while patients in the control group were treated with MEBO-impregnated cotton patch alone.The healing rate and healing time of tympanic membrane perfora-tion,hearing improvement,and occurrence of adverse drug reactions of patients were compared between the two groups.Results After 14 days of treatment,the healing rate of tympanic membrane perforation of patients was 9302%in the study group,showing no significant difference as compared with 9070%in the control group(χ^(2)=0156,P=0693).The healing time of tympanic membrane perforation of patients was(109±26)d in the study group,showing no significant difference as compared with(116±29)d in the control group(t=1179,P=0242).After treatment,the total effective rate of hearing improvement of patients was 9535%in the study group,which was obviously higher than the corresponding 7674%in the control group(χ^(2)=6198,P=0013).During the treatment,no adverse drug reactions occurred in the two groups.Conclusion Although ginkgo biloba extract cannot increase the healing rate of traumatic tympanic membrane perfo-ration,it can improve the symptoms of hearing loss without causing significant adverse reactions,deserving to be promoted in clinical practice.

关 键 词：银杏叶提取物 湿润烧伤膏 听力 鼓膜穿孔 外伤 

分 类 号：R764[医药卫生—耳鼻咽喉科]