加味小蓟饮子联合透明质酸钠治疗宫颈癌放疗后急性放射性膀胱炎疗效观察  

Effect of Modified Xiaoji Yinzi Decoction Combined with Sodium Hyaluronate in Treatment of Acute Radiation Cystitis after Radiotherapy for Cervical Cancer

作　　者：张伟平[1] 陈慧军 黄章铖 许庆辉 郑伟杰 余梓 翁剑飞[1] ZHANG Weiping;CHEN Huijun;HUANG Zhangcheng;XU Qinghui;ZHENG Weijie;YU Zi;WENG Jianfei(The Second Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine,Fuzhou,Fujian 350003,China)

机构地区：[1]福建中医药大学附属第二人民医院,福建福州350003

出　　处：《福建中医药》2024年第3期51-55,共5页Fujian Journal of Traditional Chinese Medicine

基　　金：福建省卫生健康委2023年卫生健康省级补助专项(C2023001-财政专项)。

摘　　要：目的 观察加味小蓟饮子联合透明质酸钠治疗宫颈癌放疗后急性放射性膀胱炎的临床疗效。方法选取2020年9月—2023年9月就诊于福建中医药大学附属第二人民医院泌尿外科宫颈癌放疗后急性放射性膀胱炎患者60例,按随机数字表法分为对照组和观察组各30例,最终完成54例,对照组完成26例,观察组完成28例。对照组采用单纯透明质酸钠膀胱灌注治疗,每周1次,连续3周为1个疗程;观察组在对照组的基础上加用加味小蓟饮子内服治疗。观察2组临床疗效,比较2组治疗前后尿红细胞数量、中医证候积分、膀胱黏膜充血情况、膀胱区疼痛视觉模拟评分法(VAS)评分和膀胱过度活动症患者自我评价量表(OABSS)评分等指标变化,并通过肝肾功能变化评估安全性。结果 观察组临床总效率89.29%,高于对照组69.23%(P<0.05)。与治疗前比较,2组治疗后中医证候积分、尿红细胞数量、膀胱黏膜充血程度、膀胱区疼痛VAS评分、膀胱功能OABSS评分均有改善(P<0.05);观察组在改善中医证候积分、尿红细胞数量、膀胱区疼痛VAS评分、尿失禁评分方面均优于对照组(P<0.05)。2组治疗前肝肾功能均处于正常水平,治疗后2组肝肾功能差异无统计学意义(P>0.05)。结论 加味小蓟饮子联合透明质酸钠治疗可有效改善宫颈癌放疗后急性放射性膀胱炎患者血尿和膀胱过度活动症状,减轻膀胱区疼痛,且治疗期间肝肾功能未见异常。Objective:To observe the clinical efficacy of Modified Xiaoji Yinzi Decoction combined with sodium hyaluronate in treatment of acute radiation cystitis after radiotherapy for cervical cancer.Methods:A total of 60 patients with acute radiation cystitis after cervical cancer radiotherapy who were admitted to the urology department of the Second Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine from September 2020 to September 2023 were divided into observation group and control group by random number table method,with 30 cases in each group.Finally,54 cases were completed in the study,26 cases in the control group,28 cases in the observation group.The control group was treated with bladder perfusion of sodium hyaluronate once a week for 3 weeks as a course of treatment;the observation group was treated with modified Xiaoji Yinzi Decoction combined with bladder perfusion of sodium hyaluronate,The curative effect between the two groups was compared,the number of urine routine red blood cells,the TCM syndrome scores,the congestion of bladder mucosa,the bladder pain assessment,and the over active bladder symptom score(OABSS)before and after treatment were observed,and the safety of treatment was evaluated.by liver and renal function.Results:The total clinical efficiency of the observation group was 89.29%,which was higher than that of the control group 69.23%(P<0.05).Compared with those before treatment,the TCM syndrome scores,the number of urine routine red blood cells,the congestion of bladder mucosa,the bladder pain assessment,and the OABSS were significantly improved(P<0.05).The improvement of the TCM syndrome scores,the number of urine routine red blood cells,the bladder pain assessment and the score of urinary incontinence in the observation group were better than the control group(P<0.05).No liver and renal function impairment was observed between the two groups before and after treatment(P>0.05).Conclusion:Modified Xiaoji Yinzi Decoction combined with sodium hyaluronate is effect

关 键 词：急性放射性膀胱炎 宫颈癌 放疗 血淋 加味小蓟饮子 

分 类 号：R737.33[医药卫生—肿瘤] R694.3[医药卫生—临床医学]