美沙拉嗪联合益生菌对溃疡性结肠炎患者肠黏膜屏障功能及环氧合酶-2水平的影响  

The impacts of mesalazine combined with probiotics on intestinal mucosal barrier function and COX-2 level in patients with ulcerative colitiss

作　　者：范益博[1] 胥明 Fan Yibo;Xu Ming(Department of gastroenterology,Shanghai Pudong New Area People′s Hospital,Shanghai 201299,China)

机构地区：[1]上海市浦东新区人民医院消化内科,201299

出　　处：《山西医药杂志》2024年第7期514-518,共5页Shanxi Medical Journal

基　　金：上海市浦东新区卫生健康委员会重点学科建设项目(PWZxk2022-30)。

摘　　要：目的 分析美沙拉嗪联合益生菌对溃疡性结肠炎患者肠黏膜屏障功能及环氧合酶-2(COX-2)水平的影响。方法 选择2020年3月至2021年10月我院收治的100例溃疡性结肠炎患者为研究对象,随机将其分为对照组(50例,给予美沙拉嗪治疗)和治疗组(50例,在对照组的基础上给予益生菌治疗),对比2组患者肠黏膜屏障功能指标、细胞因子水平、临床疗效以及不良反应发生情况。结果 治疗后,治疗组患者总治疗效率明显高于对照组(P<0.05)。治疗后,治疗组患者COX-2、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平低于对照组(P<0.05)。治疗后,治疗组患者血清D-乳酸(D-LA)、二胺氧化酶(DAO)、血清内霉素(ET)水平均低于对照组(P<0.05)。治疗后,2组患者不良反应总发生率差异无统计学意义(P>0.05)。结论 美沙拉嗪联合益生菌可有效改善溃疡性结肠炎患者临床症状,恢复肠粘膜屏障功能,减少炎症因子分泌,提高治疗效果。Objective To analyze the impacts of a combination of mesalazine and probiotics on intestinal mucosal barrier function and cyclooxygenase(COX)-2 level in patients with ulcerative colitis.Methods A total of 100 patients with ulcerative colitis admitted to our hospital from March 2020 to October 2021 were regarded as the study subjects.They were randomly grouped into a control group(50 cases treated with mesalazine)and a treatment group(50 cases treated with probiotics on top of the control group).The intestinal mucosal barrier function indicators,cytokine levels,clinical efficacy,and incidence of adverse reactions were compared between the two groups.Results After treatment,the total treatment efficiency of the treatment group was higher than that of the control group(P<0.05).After treatment,the levels of COX-2,tumor necrosis factor(TNF)-α,and interleukin(IL)-6 in the treatment group were lower than those in the control group(P<0.05).After treatment,the levels of D-LA,DAO,and ET in the treatment group were lower than those in the control group(P<0.05).After treatment,there was no difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of mesalazine and probiotics can effectively improve clinical symptoms,restore intestinal mucosal barrier function,reduce inflammatory factor secretion,and improve treatment effectiveness in patients with ulcerative colitis.

关 键 词：氨水杨酸 鼠李糖乳杆菌 结肠炎 溃疡性 前列腺素内过氧化物合酶类 

分 类 号：R574.62[医药卫生—消化系统]