以球麻痹为主要表现的多项神经节苷脂抗体阳性的Miller-Fisher综合征1例并文献复习  

A case of Miller-Fisher syndrome with positive multiple ganglioside antibody with bulbar paralysis as the main manifestation and literature review

作　　者：张森岭 陈峥[1] 李本奎 ZHANG Senling;CHEN Zheng;LI Benkui(No.2 Ward of Neurology Department,Hanzhong Central Hospital,Hanzhong 723000,China)

机构地区：[1]汉中市中心医院神经内科二病区,陕西汉中723000

出　　处：《临床医学研究与实践》2024年第15期13-16,共4页Clinical Research and Practice

摘　　要：目的 探讨Miller-Fisher综合征(MFS)的诊断学特征。方法 回顾性分析我院诊治的1例以球麻痹为主要表现的多项神经节苷脂抗体阳性的MFS患者的临床资料,对照吉兰-巴雷综合征(GBS)常见类型及临床表现进行分析探讨。结果 GQ1b抗体是MFS患者发病的关键因素,可引起视神经损害和延髓麻痹的症状。结论 MFS患者的临床表现常不典型,GQ1b抗体的沉淀部位与临床表现有相关性,不典型的MFS患者可表现为以球麻痹症状起病。Objective To investigate the diagnostic characteristics of Miller-Fisher syndrome(MFS).Methods The clinical data of one patient with positive multiple ganglioside antibody MFS with bulbar paralysis as the main manifestation in our hospital were retrospectively analyzed.The common types and clinical manifestations of Guillain-Barre syndrome(GBS)were analyzed and discussed.Results GQ1b antibody was a key factor in the pathogenesis of MFS patients,which can cause symptoms of optic nerve damage and bulbar paralysis.Conclusion The clinical manifestations of MFS patients are often atypical.The precipitation site of GQ1b antibody is related to the clinical manifestations.Atypical MFS patients may begin with bulbar paralysis symptom.

关 键 词：MILLER-FISHER综合征 球麻痹 GQ1b抗体阳性 神经节苷脂抗体阳性 

分 类 号：R745.43[医药卫生—神经病学与精神病学]