CDK12、STAT3在乳腺癌组织中的表达及与病理参数的关系  

Expression of CDK12 and STAT3 in breast cancer tissues and their relationship with pathological parameters

作　　者：万立会 WAN Lihui(Pathology Department,Zhumadian TCM Hospital,Zhumadian 463000,China)

机构地区：[1]驻马店市中医院病理科,河南驻马店463000

出　　处：《临床医学研究与实践》2024年第15期104-107,共4页Clinical Research and Practice

摘　　要：目的 探讨乳腺癌组织中细胞周期蛋白依赖性激酶12(CDK12)、信号转导及转录活化因子3(STAT3)表达情况及与病理参数的关系。方法 选取我院2016年1月至2019年12月收治的123例(均完成3年随访)女性乳腺癌患者为研究对象,采用免疫组化法检测乳腺癌组织和癌旁组织中CDK12、STAT3的表达情况。比较不同病理参数乳腺癌组织中CDK12、STAT3的表达情况,并分析CDK12、STAT3表达与病理参数及患者预后的关系。结果 乳腺癌组织中CDK12、STAT3阳性表达率均高于癌旁组织(P<0.05)。乳腺癌组织CDK12、STAT3阳性表达率:Ⅰ~Ⅱ期低于Ⅲ~Ⅳ期,无淋巴结转移低于有淋巴结转移;不同分化程度乳腺癌组织CDK12、STAT3阳性率差异显著(P<0.05)。乳腺癌组织中CDK12、STAT3阳性表达率与临床分期、淋巴结转移呈正相关,与分化程度呈负相关(P<0.05)。CDK12、STAT3阳性乳腺癌患者的3年生存率分别低于其阴性患者(P<0.05)。结论 乳腺癌患者组织中CDK12、STAT3呈现高表达,与乳腺癌的临床分期、淋巴结转移及预后有紧密关系,可作为临床判断病情、评估预后的有效指标。Objective To investigate the expression of cyclin-dependent kinase 12(CDK12)and signal transducer and activator of transcription 3(STAT3)in breast cancer tissues and their relationship with pathological parameters.Methods A total of 123 female breast cancer patients(all completed 3-year follow-up)admitted in our hospital from January 2016 to December 2019 were selected as the research objects.The expression of CDK12 and STAT3 in breast cancer tissues and adjacent tissues was detected by immunohistochemistry.The expression of CDK12 and STAT3 in breast cancer tissues with different pathological parameters were compared,and the relationship between the expression of CDK12 and STAT3 and pathological parameters and prognosis of patients were analyzed.Results The positive expression rates of CDK12 and STAT3 in breast cancer tissues were higher than those in adjacent tissues(P<0.05).The positive expression rates of CDK12 and STAT3 in breast cancer tissues:Ⅰ-Ⅱstage were lower thoseⅢ-Ⅳstage,and no lymph node metastasis were lower those lymph node metastasis;the positive expression rates of CDK12 and STAT3 in brease cancer tissues with different degrees of differentiation were significantly different(P<0.05).The positive expression rates of CDK12 and STAT3 in breast cancer tissues were positively correlated with clinical stage and lymph node metastasis,and negatively correlated with the degree of differentiation(P<0.05).The 3-year survival rates of CDK12 and STAT3 positive breast cancer patients were lower than those of their negative patients(P<0.05).Conclusion The high expression of CDK12 and STAT3 in breast cancer tissues is closely related to the clinical stage,lymph node metastasis and prognosis of breast cancer,which can be used as an effective indexes for clinical judgment and prognosis evaluation.

关 键 词：乳腺癌 病理参数 细胞周期蛋白依赖性激酶12 信号转导及转录活化因子3 预后 

分 类 号：R737.33[医药卫生—肿瘤]