血清AFP、CEA、NSE、CYFRA211在非小细胞肺癌诊断中的应用价值分析  

The Diagnostic Value of Serum AFP,CEA,NSE and CYFRA211 in Non-Small Cell Lung Cancer

作　　者：郝顺 张玉侠 HAO Shun;ZHANG Yuxia(Department of Nuclear Medicine,the Third Affiliated Hospital of Xuzhou Medical University,Jiangsu Xuzhou 221003,China;Department of Laboratory Medicine,the Third Affiliated Hospital of Xuzhou Medical University,Jiangsu Xuzhou 221003,China)

机构地区：[1]徐州医科大学附属第三医院核医学科,江苏徐州221003 [2]徐州医科大学附属第三医院检验科,江苏徐州221003

出　　处：《中国医药导刊》2024年第3期280-284,共5页Chinese Journal of Medicinal Guide

摘　　要：目的:探讨血清甲胎蛋白(alpha-fetoprotein,AFP)、癌胚抗原(carcinoembryonic antigen,CEA)、神经元特异性烯醇化酶(neuron-specific enolase,NSE)、可溶性细胞角蛋白19片段(CYFRA211)在非小细胞肺癌诊断中的应用价值。方法:收集2021年1月至2022年12月我院收治确诊的非小细胞肺癌患者80例以及肺部良性病变患者80例的临床资料实施回顾性分析。对比两组患者的血清肿瘤标志物定量检查结果、血清肿瘤标志物检查结果的阳性率。对单独使用各血清肿瘤标志物对非小细胞肺癌的诊断效能进行对比。分析以血清肿瘤标志物诊断非小细胞肺癌的独立影响因素。结果:非小细胞肺癌组患者的血清CEA、NSE、CYFRA211浓度数值均高于肺部良性病变组患者(P<0.05)。两组患者AFP阳性率比较,差异无统计学意义(P>0.05)。非小细胞肺癌组患者的CEA、NSE、CYFRA211阳性率均高于肺良性病变组患者(P<0.05)。在单独使用各血清肿瘤标志物对非小细胞肺癌进行诊断时,CEA、NSE、CYFRA211的诊断灵敏度、阴性预测值以及Kappa值均高于AFP(P<0.05)。多因素Logistic分析结果显示,CEA、NSE、CYFRA211阳性是患者以血清肿瘤标志物诊断为非小细胞肺癌的独立危险因素(P<0.05)。结论:血清CEA、NSE、CYFRA211在非小细胞肺癌诊断中具有良好的效能。Objective:To investigate the application value of serum alpha-fetoprotein(AFP),carcinoembryonic antigen(CEA),neuron-specific enolase(NSE),and soluble cytokeratin 19 fragment(CYFRA211)in the diagnosis of non-small cell lung cancer(NSCLC).Methods:The clinical data of 80 patients with NSCLC and 80 patients with benign lung lesions admitted to our hospital from January 2021 to December 2022 were retrospectively analyzed.The quantitative results of serum tumor markers and the positive rate of serum tumor markers were compared between the two groups.The efficacy of each serum tumor markers in diagnosing NSCLC was compared.The independent factors influencing the diagnosis of NSCLC by serum tumor markers were analyzed.Results:The serum CEA,NSE and CYFRA211 levels of patients in the NSCLC group were higher than those of the benign lung lesion group(P<0.05).There was no statistical difference in the positive rate of AFP between the two groups(P>0.05).The positive rates of CEA,NSE and CYFRA211 in the NSCLC group were higher than those of the benign lung lesion group(P<0.05).The diagnostic sensitivity,negative predictive value and Kappa value of CEA,NSE and CYFRA211 were higher than those of AFP when each serum tumor marker was used alone in the diagnosis of NSCLC(P<0.05).Multivariate Logistic analysis showed that CEA,NSE and CYFRA211 positivity were independent risk factors for diagnosing NSCLC by serum tumor markers(P<0.05).Conclusion:Serum CEA,NSE and CYFRA211 have good diagnostic values for NSCLC.

关 键 词：甲胎蛋白 癌胚抗原 神经元特异性烯醇化酶 非小细胞肺癌 血清肿瘤标志物 

分 类 号：R734.2[医药卫生—肿瘤]