皮肤镜和反射式共聚焦显微镜在角质形成细胞皮肤肿瘤中的应用  

The Application of Dermatoscopy and Reflective Confocal Microscopy in Keratinocyte Skin Tumors

作　　者：徐红艳 王佩茹 王秀丽[1] XU Hongyan;WANG Peiru;WANG Xiuli(Institute of Photomedicine,Shanghai Skin Disease Hospital,Tongji University School of Medicine,Shanghai 200443,China)

机构地区：[1]上海市皮肤病医院,同济大学医学院光医学研究所,上海200443

出　　处：《皮肤科学通报》2024年第2期137-142,共6页Dermatology Bulletin

基　　金：国家重点研发计划-常见病防治专项(2022YFC2504705);上海申康医院发展中心第二轮《促进市级医院临床技能与临床创新三年行动计划》研究型医师创新转化能力培训项目(SHDC2022CRT017);上海市皮肤病医院临床研究培育项目(lcfy2020-09)。

摘　　要：角质形成细胞皮肤肿瘤(KSC)是一类发病率逐年上升的肿瘤,与年紫外线辐射量直接相关,根据不同阶段可以分为光线性角化病(actinic keratosis, AK)、鲍温病(Bowen′s disease, BD)和侵袭性鳞状细胞癌(invasive squamous cell carcinoma, SCC)。KSC的诊断主要通过组织病理学确诊,但早期筛查以及后期随访,无创诊断显得尤为重要。皮肤镜(dermoscopy)和反射式共聚焦显微镜(reflectance confocal microscopy, RCM)属于在体观测皮肤表面以及表皮以下细微结构的无创诊断技术,在皮肤疾病诊断中具有极高的应用价值。本文主要总结并探讨KSC在皮肤镜和RCM下的表现特征以及皮肤镜和RCM在KSC的诊断、筛查和随访中的应用。Keratinocyte skin cancer(KSC)is a kind of tumor with increasing incidence rate year by year,which is directly related to annual ultraviolet radiation.KSC stands for different stages of skin cancer including actinic keratosis(AK),Bowen′s Disease(BD)and invasive squamous cell carcinoma(SCC).The diagnosis of KSC is mainly confirmed through histopathology.Non-invasive diagnosis is particularly important in the screening and follow-up of KSC.Dermoscopy and reflection confocal microscopy(RCM)are non-invasive diagnostic techniques for observing the surface and sub epidermal structures of the skin in vivo.Dermoscopy and RCM have extremely high application value in the diagnosis of skin diseases.This article mainly summarizes the characteristics of KSC under dermatoscopy and RCM,as well as the application of dermatoscopy and RCM in assisting the diagnosis,screening and follow-up of KSC.

关 键 词：皮肤镜 反射式共聚焦显微镜 角质形成细胞皮肤肿瘤 光线性角化病 鲍温病 鳞状细胞癌 

分 类 号：R739.5[医药卫生—肿瘤] R751[医药卫生—临床医学]