根除幽门螺杆菌对胃黏膜癌前状态和癌前病变影响及机制的研究进展  

Research progress on the effect and mechanism of Helicobacter pylori eradication on gastric mucosal precancerous conditions and lesions

作　　者：周举坤 张晓彤 孙振灿 王军[2,3] 郑亚 王玉平[2,4] 姬瑞[2,3,4] ZHOU Jukun;ZHANG Xiaotong;SUN Zhencan;WANG Jun;ZHENG Ya;WANG Yuping;JI Rui(The First Clinical Medical College of Lanzhou University,Lanzhou 730000;Department of Gastroenterology,the First Hospital of Lanzhou University;Digestive Endoscope Center,the First Hospital of Lanzhou University;The First Hospital of Lanzhou University,Gansu Province Clinical Research Center for Digestive Diseases,China)

机构地区：[1]兰州大学第一临床医学院,甘肃兰州730000 [2]兰州大学第一医院消化科 [3]兰州大学第一医院消化内镜中心 [4]兰州大学第一医院,甘肃省消化系疾病临床研究中心

出　　处：《胃肠病学和肝病学杂志》2024年第5期594-598,共5页Chinese Journal of Gastroenterology and Hepatology

基　　金：甘肃省自然科学基金(22JR5RA906);兰州市人才创新创业项目(2019-RC-33);兰州大学第一医院院内基金(ldyyyn2021-95)。

摘　　要：胃癌居全球肿瘤死因第三位,总生存率低,治疗预后差。幽门螺杆菌(Helicobacter pylori,H.pylori)是胃癌发生的主要原因之一,世界上一半人口感染H.pylori。H.pylori感染也是胃癌前病变(precancerous lesions of gastric cancer,PLGC)发生的重要原因,PLGC与胃癌发生密切相关,在病变早期阶段,延缓或逆转PLGC则成为治疗和预防胃癌的关键。本文综述了PLGC的进展过程中根除H.pylori的重要性及有效性,旨在为临床治疗提供更多参考。Gastric cancer is the third leading cause of cancer death in the world,with a low overall survival rate and a poor prognosis.H.pylori is one of the main causes of gastric cancer.Half of the world′s population is infected with H.pylori.H.pylori infection is also an important cause of precancerous lessions of gastric cancer(PLGC).PLGC is closely related to the occurrence of gastric cancer.In the early stage of gastric lesions,delaying or reversing PLGC is the key to the treatment and prevention of gastric cancer.This article reviewed the importance and effectiveness of eradicating H.pylori in the progress of PLGC,in order to provide more references for clinical treatment.

关 键 词：幽门螺杆菌 胃癌前病变 化学预防 治疗 

分 类 号：R735.2[医药卫生—肿瘤]