肝胆损伤后胆管反应的调控机制及标志物的研究现状  

Research status of regulation mechanism and related markers of ductular reaction after hepatobiliary injury

作　　者：柏承志 官敏 汤善宏 BAI Chengzhi;GUAN Min;TANG Shanhong(Department of Gastroenterology,the General Hospital of Western Theater Command,Chengdu 610083;Southwest Jiaotong University College of Medicine,China)

机构地区：[1]西部战区总医院消化内科,四川成都610083 [2]西南交通大学医学院

出　　处：《胃肠病学和肝病学杂志》2024年第5期623-627,共5页Chinese Journal of Gastroenterology and Hepatology

基　　金：四川省中医药管理局科学技术研究专项课题(2023MS458)。

摘　　要：胆管反应存在于多种肝胆损伤疾病中,并在其预后与疾病进展方面具有独特的临床意义。当前的研究多集中于胆管反应的发生与调控机制,这将有助于我们更好地理解胆管反应的临床意义并挖掘更多的治疗靶点。此外,胆管反应相关标志物在预测疾病预后与进展方面也具备一定作用,但目前对此的关注相对较少。本文旨在总结近年来在胆管反应调控机制方面的研究进展并提出当前对胆管反应相关标志物的研究现状。Ductular reaction exists in a variety of hepatobiliary injury diseases,and has unique clinical significance in its prognosis and disease progression.Current research focuses on the occurrence and regulation mechanism of ductular reaction,which will help us better understand the clinical significance of ductular reaction and explore more therapeutic targets.In addition,ductular reaction-related markers also play a role in predicting the prognosis and progression of the disease,but relatively little attention has been paid to this.This paper aimed to summarize the research progress in the regulation mechanism of ductular reaction in recent years and propose the current research status of ductular reaction-related markers.

关 键 词：胆管反应 肝祖细胞 胆管上皮细胞 生物标记 

分 类 号：R575.6[医药卫生—消化系统]