年龄相关性黄斑变性所致地图样萎缩的研究进展  

Research advance in geographic atrophy due to age-related macular degeneration

作　　者：王博昭 张鹏[1] Wang Bozhao;Zhang Peng(Xi an No.3 Hospital,the Affiliated Hospital of Northwest University,Xi an 710018,Shaanxi Province,China)

机构地区：[1]中国陕西省西安市第三医院、西北大学附属医院,710018

出　　处：《国际眼科杂志》2024年第6期899-901,共3页International Eye Science

摘　　要：地图样萎缩是年龄相关性黄斑变性(ARMD)的一种中期及进展期表现。由于地图样萎缩发病机制复杂,目前尚无强有效的治疗方法,患者最终将丧失中心视力。研究显示,补体系统的过度激活与地图样萎缩的发生及进展密切相关。文章就地图样萎缩的临床表现、发病机制、补体系统在发病进程中的作用及治疗进展等进行综述。Geographic atrophy(GA)is an intermediate and advanced stage of age-related macular degeneration(ARMD).Due to the complex pathogenesis of GA,there are no effective treatments at present,and eventually patients will lose central vision.Studies have shown that excessive activation of the complement system is closely related to the occurrence and progression of GA.This review will offer a summary of the clinical features,pathogenesis,the role of complement system in the pathology and the treatment progress of GA.

关 键 词：年龄相关性黄斑变性 地图样萎缩 补体系统 治疗 进展 

分 类 号：R774.5[医药卫生—眼科]