Electroacupuncture targeting the immune system to alleviate sepsis  

作　　者：Mengyue Fang Yuye Lan Man Li Chennan Li Bin Xu Yan Ma Sulukkana Noiprasert Xianghong Jing Lingling Yu 

机构地区：[1]Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China [2]School of Basic Medicine,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China [3]Key Laboratory of Integrated Acupuncture and Medicine Research of Ministry of Education,Nanjing University of Chinese Medicine,Nanjing,China [4]Wuhan No.1 Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China [5]School of Integrative Medicine,Mae Fah Luang University,Chiangrai,Thailand [6]Institute of Acupuncture and Moxibustion,China Academy of Chinese Medical Sciences,Beijing,China [7]Institute of Integrated Traditional Chinese and Western Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China

出　　处：《Acupuncture and Herbal Medicine》2024年第1期56-67,共12页针灸和草药（英文）

基　　金：funded by the National Key Research and Development Program(2022YFC3500704);the National Natural Science Foundation of China(82174500,82004491).

摘　　要：Sepsis is a life-threatening inflammatory syndrome with high morbidity and mortality rates.However,options for sepsis are still limited to general treatment in intensive care units(ICUs),and effective therapies that improve sepsis survival are required.Immune disturbances play a vital role in the pathology of sepsis and are associated with protracted inflammation,susceptibility to infections,and death.Therefore,many investigators have focused on the potential benefits of immunomodulation therapy for sepsis.Electroacupuncture(EA)has been practiced in clinics for many years and has shown advantages in treating infectious diseases.Over the last few decades,our understanding of the efficacy and mechanisms of EA in sepsis has undergone considerable developments.We searched the literature regarding“CNKI,Wan Fang Data,VIP Database,PubMed,and Ingenta Connect”from 2010 to 2023,using the keywords“sepsis”“septic”and“electroacupuncture”and 336 sources were searched.Finally,we included 82 studies that targeted the immune system to determine EA’s anti-inflammatory and immunomodulatory effects on sepsis.In this review,we found that EA has clinical benefits in relieving septic inflammation,improving immune function,and attenuating related multi-organ injury through several mechanisms,such as activation of the cholinergic anti-inflammatory pathway(CAP),vagaladrenal axis,inhibition of the nuclear factor Kappa-B(NF-κB)signaling pathway,signal transducers and activators of transcription(STAT)signaling pathway,and improvement of immune cell function.Therefore,EA may be a promising complementary therapy for sepsis treatment.We also expect these data will contribute to further studies on EA in sepsis.

关 键 词：Cholinergic anti-inflammatory pathway ELECTROACUPUNCTURE Nuclear factor Kappa-B SEPSIS Signal transducers and activators of transcription Vagal-adrenal axis 

分 类 号：R515.3[医药卫生—内科学]