Licorice:comprehensive review of its chemical composition,pharmacodynamics,and medicinal value  

作　　者：Lingling Dang Yajing Jin Ye Yuan Rui Shao Yu Wang 

机构地区：[1]School of Integrative Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin,China [2]State Key Laboratory of Component-Based Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin,China

出　　处：《Acupuncture and Herbal Medicine》2024年第1期136-150,共15页针灸和草药（英文）

基　　金：funded by the National Natural Science Foundation of China(82204878).

摘　　要：Licorice,a perennial herb of Leguminosa,is one of the oldest and most widely used herbal medicines worldwide.Its distinct sweet flavor and rich medicinal value make it an integral component of traditional Chinese medicine(TCM)formulations,which continue to be widely employed.The main chemical constituents of licorice include triterpenoid saponins,flavonoids,and polysaccharides.Experimental and clinical studies have demonstrated that various extracts and pure compounds derived from licorice exhibit a wide range of pharmacological properties including anti-inflammatory,antioxidant,antimicrobial,antiviral,antitumor,immune-regulatory,and neuroprotective activities.The bioactive constituents of licorice offer therapeutic benefits for cardiovascular and cerebrovascular diseases,diabetes mellitus,and liver disorders.This comprehensive review discusses the primary chemical constituents of licorice and their pharmacological activities,describes in vivo and in vitro models employed for studying licorice,and its potential targets and mechanisms of action.Furthermore,we discuss the toxicological profile,side effects,dosage recommendations,and clinical applications of licorice.This review aims to establish a foundation for further research on the safe and effective utilization of licorice while facilitating an in-depth exploration of its properties and fostering the development of novel therapeutic agents.

关 键 词：Active ingredients Clinical application LICORICE Pharmacological activity 

分 类 号：R28[医药卫生—中药学]