The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia  

作　　者：Xiaorong Zhang Zhiying Chen Yinyi Xiong Qin Zhou Ling-Qiang Zhu Dan Liu 

机构地区：[1]Department of Pathology,Affiliated Hospital of Jiujiang University,Jiujiang,Jiangxi Province,China [2]Jiujiang Clinical Precision Medicine Research Center,Jiujiang,Jiangxi Province,China [3]Center for Cognitive Science and Transdisciplinary Studies,Jiujiang University,Jiangxi Province,China [4]Department of Neurology,Affiliated Hospital of Jiujiang University,Jiujiang,Jiangxi Province,China [5]Department of Rehabilitation,Affiliated Hospital of Jiujiang University,Jiujiang,Jiangxi Province,China [6]Department of Pathophysiology,School of Basic Medicine,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei Province,China

出　　处：《Neural Regeneration Research》2025年第2期402-415,共14页中国神经再生研究（英文版）

基　　金：supported by the National Key R&D Program of China,No.2019YFE0121200(to LQZ);the National Natural Science Foundation of China,Nos.82325017(to LQZ),82030032(to LQZ),82261138555(to DL);the Natural Science Foundation of Hubei Province,No.2022CFA004(to LQZ);the Natural Science Foundation of Jiangxi Province,No.20224BAB206040(to XZ);Research Project of Cognitive Science and Transdisciplinary Studies Center of Jiangxi Province,No.RZYB202201(to XZ).

摘　　要：With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic rate.However,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia patients.Similarly in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive decline.Nitric oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous system.Recently,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular dementia.This review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular dementia.Additionally,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关 键 词：endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia 

分 类 号：R749.13[医药卫生—神经病学与精神病学]