Whipple术后继发性草酸盐肾病  

Secondary oxalate nephropathy after Whipple surgery

作　　者：徐静[1] 郝家琪 唐晓晴 潘晓霞[1,4] XU Jing;HAO Jiaqi;TANG Xiaoqing;PAN Xiaoxia(Department of Nephrology,Institute of Nephrology,Shanghai Ruijin Hospital,Shanghai Jiao Tong University,School of Medicine,Shanghai 200025,China;Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China;Department of Nephrology,Shanghai Tenth People s Hospital,Tongji University School of Medicine,Shanghai,Shanghai 200072,China;Department of Nephrology,Ruijin-Hainan Hospital,Shanghai Jiao Tong University,School of Medicine(Hainan Boao Research Hospital),Hainan 571437,China)

机构地区：[1]上海交通大学医学院附属瑞金医院肾脏科,上海200025 [2]上海交通大学医学院临床医学系 [3]上海同济大学附属第十人民医院肾脏科 [4]上海交通大学医学院附属瑞金医院海南医院(海南博鳌研究型医院)肾脏科

出　　处：《肾脏病与透析肾移植杂志》2024年第2期187-191,共5页Chinese Journal of Nephrology,Dialysis & Transplantation

基　　金：国家自然科学基金(81900606);上海市临床重点专科建设项目(shslczdzk02502)

摘　　要：67岁男性患者,3年前因胰头肿瘤行Whipple术,发病前数月服用中草药茶。肾脏损害表现为血清肌酐逐渐升高伴少量蛋白尿,肾脏病理表现为肾小管间质病变(慢性基础上急性加重),肾小管腔内较多偏振光下折光呈五彩斑斓的结晶沉积,最终诊断为继发性高草酸尿症所致草酸盐肾病。给予低草酸饮食、多饮水、维生素B6及消胆胺等治疗3月后肾功能好转。A 67-year-old male,presented with serum creatinine increased gradually accompanied with few proteinuria.The patient underwent Whipple surgery for pancreatic tumor 3 years ago and took Chinese herbal tea in recent months.Renal biopsy revealed interstitial and tubular lesions(acute on chronic),a large amount of crystal deposited in renal tubular lumen which exhibit colorful refraction under polarized light,ultimately diagnosed as oxalate nephropathy due to secondary hyperoxaluria.The renal function improved after 3 months of treatment with a low oxalate diet,plenty of drinking water,vitamin B6 and cholestastyramine.

关 键 词：高草酸尿症 草酸盐肾病 WHIPPLE术 

分 类 号：R735.9[医药卫生—肿瘤] R692[医药卫生—临床医学]