精神分裂症患者炎症细胞因子水平与精神症状的相关性分析  

Analysis of the correlation between inflammatory cytokines and mental symptoms in schizophrenic patientsy

作　　者：谢孟杰[1] 张卫国 陈大春[2] 辛闻 Xie Mengjie;Zhang Weiguo;Chen Dachun;Xin Wen(Department of Psychiatry,The Third Hospital of Beijing Chaoyang District,Beijing 100121,China)

机构地区：[1]北京市朝阳区第三医院精神科,100121 [2]北京回龙观医院精神科

出　　处：《北京医学》2024年第3期199-203,共5页Beijing Medical Journal

基　　金：首都卫生发展科研专项(首发2018-2-2131)。

摘　　要：目的探讨首次发病(以下简称首发)精神分裂症患者的炎症细胞因子水平及其与精神症状的相关性。方法选取2018—2019年北京回龙观医院首发精神分裂症住院患者98例(患者组)和医院周边社区健康人群64例(对照组),采用酶联免疫吸附法测定研究对象血清炎症细胞因子水平,比较两组血清炎症细胞因子水平,并采用阳性与阴性症状量表(positive and negative syndrome scale,PANSS)评价患者组精神症状的严重程度,采用Pearson相关法分析炎症细胞因子水平与精神症状的相关性。结果162例研究对象中男64例、女98例;年龄18~45岁,平均(30.4±9.1)岁。与对照组相比,患者组的IL-1[(121.95±14.18)μg/ml比(79.19±15.62)μg/ml]、IL-4[(38.16±5.43)μg/ml比(22.02±5.58)μg/ml]、IL-6[(44.64±6.17)μg/ml比(30.30±5.50)μg/ml]和TNF-α[(66.15±9.84)μg/ml比(42.79±9.00)μg/ml]较高,差异均有统计学意义(P<0.05)。Pearson相关分析结果显示,患者组IL-1、IL-4、IL-6和TNF-α与PANSS总分、阴性症状、阳性症状和一般精神病理症状均无相关性(P>0.05)。结论首发精神分裂症患者的炎症细胞因子水平较高,但与精神症状的严重程度无相关性。Objective The explore the level of inflammatory cytokines and its correlation with mental symptoms in patients with first-episode schizophrenia.Methods A total of 98 patients with first-episode schizophrenia(case group)of Huilongguan Hospital of Beijing and 64 healthy subjects from the community around the hospital(control group)were selected from 2018 to 2019.Inflammatory cytokines levels of all the subjects were measured by enzyme-linked immunosorbent assay(ELISA)and were compared between the two groups,the positive and negative syndrome scale(PANSS)was used to evaluate the mental symptoms of schizophrenia patients,and the Pearson correlation was used to analyze the correlation between inflammatory cytokines and mental symptoms.Results Among the 162 subjects,there were 64 males and 98 females,age from 18~45 years old,with an average age of(30.4±9.1)years.Compared with the control group,the levels of IL-1[(121.95±14.18)μg/ml vs.(79.19±15.62)μg/ml]、IL-4[(38.16±5.43)μg/ml vs.(22.02±5.58)μg/ml]、IL-6[(44.64±6.17)μg/ml vs.(30.30±5.50)μg/ml]and TNF-α[(66.15±9.84)μg/ml vs.(42.79±9.00)μg/ml]in case group were higher,the differrences were statistically significant(all P<0.05).Pearson correlation analysis showed that IL-1,IL-4,IL-6 and TNF-αwere not correlated with the total score,negative symptoms,positive symptoms and general symptoms of PANSS(P>0.05).Conclusions The levels of inflammatory cytokines in patients with first-episode schizophrenia are high,but there is no correlation with the severity of mental symptoms.

关 键 词：精神分裂症 炎症细胞因子 精神病理 相关性 

分 类 号：R749.3[医药卫生—神经病学与精神病学]