自发性脑出血急性期患者风险因素及血清Tau蛋白、MIP-1a、NLR与患者预后的关系  

Risk factors and the relationship between serum Tau protein,MIP-1α,NLR and prognosis in patients with acute spontaneous cerebral hemorrhage

作　　者：肖波 石碑田 侯仕强 XIAO Bo;SHI Beitian;HOU Shiqiang(Department of Neurosurgery,Chuzhou Hospital affiliated to Anhui Medical University(Chuzhou First People's Hospital),Chuzhou Anhui 239000,China)

机构地区：[1]安徽医科大学附属滁州医院(滁州市第一人民医院)神经外科,安徽滁州239000

出　　处：《中国急救复苏与灾害医学杂志》2024年第5期591-594,606,共5页China Journal of Emergency Resuscitation and Disaster Medicine

基　　金：安徽省重点研究与开发计划(编号:2022e07020069)。

摘　　要：目的探讨自发性脑出血急性期患者风险因素及血清Tau蛋白、巨噬细胞炎症蛋白1a(MIP-1a)、中性粒细胞与淋巴细胞比值(NLR)与患者预后的关系。方法选取2020年1月—2022年6月在安徽医科大学附属滁州医院治疗的自发性脑出血患者59例作为观察组,以1∶2配对(性别、年龄)选取同期神经外科治疗的非自发性脑出血患者118例作为对照组,比较两组患者临床资料及血清Tau蛋白、MIP-1a、NLR差异,采用Logistic回归分析自发性脑出血发生的危险因素;同时分析观察组不同预后患者临床资料及血清Tau蛋白、MIP-1a、NLR差异,采用ROC曲线分析三者预测预后不良的价值。结果观察组和对照组高血压分级、高血压病史、吸烟史、吸烟量、饮酒量比较差异有统计学意义(P<0.05)。观察组血清Tau蛋白、MIP-1a和NLR分别为(290.30±45.54)ng/L、(91.18±21.22)ng/L和(2.98±0.87),明显高于对照组(P<0.05)。Logistic回归分析显示:高血压分级、高血压病史、吸烟史、吸烟量、饮酒量是自发性脑出血发生的影响因素(P<0.05)。观察组预后不良患者Tau蛋白、MIP-1a和NLR分别为(308.83±35.55)ng/L、(103.32±28.93)ng/L和(3.21±0.90),明显高于预后良好患者(P<0.05)。Tau蛋白、MIP-1a和NLR预测自发性脑出血患者预后不良的ROC曲线下面积分别为0.787、0.745和0.830,P<0.05。结论自发性脑出血发生受高血压、吸烟及饮酒的影响,血清Tau蛋白、MIP-1a、NLR与自发性脑出血患者预后有关,在预测患者预后方面有一定的应用价值。Objective To investigate the risk factors of patients with spontaneous intracerebral hemorrhage at the acute stage and their relationship with serum Tau protein,macrophage inflammatory protein 1α(MIP-1α),neutrophil lymphocyte ratio(NLR).Methods 59 patients with spontaneous intracerebral hemorrhage who were treated in our hospital from January 2020 to June 2022 were selected as the observation group,and 118 patients with non-spontaneous intracerebral hemorrhage who were treated in our hospital in the same period were selected as the control group with 1∶2 matching(gender,age).The clinical data,serum Tau protein,MIP-1α,and NLR of the two groups were compared,Logistic regression analysis was used to analyze the risk factors of spontaneous cerebral hemorrhage;at the same time,the clinical data,serum Tau protein,MIP-1αand NLR of patients with different prognosis in the observation group were analyzed,The predicting poor prognosis value of them were analyzed by ROC curve.Results There were statistically significant differences between the observation group and the control group in hypertension grading,hypertension history,smoking history,smoking volume,and alcohol consumption(P<0.05).The serum Tau protein,MIP-1αand NLR in the observation group were(290.30±45.54)ng/L,(91.18±21.22)ng/L and(2.98±0.87),respectively,which was significantly higher than those in the control group(P<0.05).Logistic regression analysis showed that hypertension grade,hypertension history,smoking history,smoking volume,and alcohol consumption were the influencing factors of spontaneous cerebral hemorrhage(P<0.05).Tau protein,MIP-1αand NLR in patients with poor prognosis in the observation group were(308.83±35.55)ng/L,(103.32±28.93)ng/L and(3.21±0.90),which were significantly higher than those in patients with good prognosis(P<0.05).The areas under the ROC curve predicted by Tau protein,MIP-1αand NLR for poor prognosis in patients with spontaneous cerebral hemorrhage were 0.787,0.745 and 0.830,respectively(P<0.05).Conclusion The occu

关 键 词：自发性脑出血 风险因素 TAU蛋白 巨噬细胞炎症蛋白1a 中性粒细胞与淋巴细胞比值 预后 

分 类 号：R743.34[医药卫生—神经病学与精神病学]