微RNA生物学功能及其与卵巢癌相关性的研究进展  

Research progress on the biological function of microRNA and its correlation with ovarian cancer

作　　者：周宇恒 李玥潼 张帅辉 邓雨宸 刘中原 陈柏君 丁琳 ZHOU Yuheng;LI Yuetong;ZHANG Shuaihui;DENG Yuchen;LIU Zhongyuan;CHEN Baijun;DING Lin(Medical Department of Xinglin College,Nantong University,Nantong 226000,Jiangsu Province,China;School of Public Health,Nantong University,Nantong 226000,Jiangsu Province,China;General Introduction to Surgery Teaching and Research Office,Medical School of Nantong University,Nantong 226000,Jiangsu Province,China)

机构地区：[1]南通大学杏林学院医学部,江苏南通226000 [2]南通大学公共卫生学院,江苏南通226000 [3]南通大学医学院外科学总论教研室,江苏南通226000

出　　处：《数理医药学杂志》2024年第5期385-391,共7页Journal of Mathematical Medicine

摘　　要：卵巢癌(ovarian carcinoma,OC)是女性常见三大原发恶性肿瘤之一,严重危害女性生殖健康。由于其隐匿性高、易耐药、易复发的特点,导致患者预后较差、病死率极高。微RNA(microRNA,miRNA)是一类小分子单链非编码RNA,主要通过特异性抑制翻译或降解靶mRNA,在转录后水平上发挥基因表达调控作用。多种miRNA已被证实在OC中异常表达,并在调控细胞迁移侵袭、耐药、血管生成以及肿瘤微环境等方面发挥核心作用。本文就miRNA生物学功能、miRNA在OC中的作用进行综述,以为OC的诊治、预后及干预靶点等提供参考。Ovarian cancer(OC)is one of the three common primary malignant tumors in women,which seriously endangers the reproductive health.Due to its high concealment,susceptibility to drug resistance,and susceptibility to recurrence,the prognosis of patients is poor and the mortality rate is extremely high.MicroRNA(miRNA)is a type of small molecule single stranded non coding RNA that primarily exerts gene expression regulation at the post transcriptional level by specifically inhibiting translation or degrading target mRNA.Multiple miRNAs have been confirmed to be abnormally expressed in OC and play a core role in regulating cell migration and invasion,drug resistance,angiogenesis,and tumor microenvironment.This article reviews the biological functions of miRNA and its role in OC,in order to provide references for the diagnosis,treatment,prognosis and intervention targets of OC.

关 键 词：卵巢癌 微RNA 耐药 侵袭 转移 靶点 

分 类 号：R737.31[医药卫生—肿瘤]