Ten- year follow- up investigation of stroke risk in systemic lupus erythematosus  

作　　者：Jin-An Huang Ching-Heng Lin Ming-Ju Wu Yi-Hsing Chen Kuo-Cheng Chang Chung-Wei Hou 

机构地区：[1]Division of Neurology,Neurological Institute,Taichung Veterans General Hospital,Taichung,Taiwan,China [2]Department of Health Business Administration,Hungkuang University,Taichung,Taiwan,China [3]Department of Medical Research,Taichung Veterans General Hospital,Taichung,Taiwan,China [4]Division of Nephrology,Department of Internal Medicine,Taichung Veterans General Hospital,Taichung,Taiwan,China [5]School of Medicine,Chung Shan Medical University,Taichung,Taiwan,China [6]College of Medicine,Taiwan Chung Hsing University,Taichung,Taiwan,China [7]Division of Allergy,Immunology and Rheumatology,Department of Internal Medicine,Taichung Veterans General Hospital,Taichung,Taiwan,China [8]School of Medicine,Taiwan Yang-Ming Chiao Tung University,Taichung,Taiwan,China

出　　处：《Stroke & Vascular Neurology》2024年第1期1-7,共7页卒中与血管神经病学(英文)

基　　金：supported in part by grants from Taichung Veterans General Hospital,Taiwan(TCVGH-NHRI10703).

摘　　要：Background and purpose To analyse the long-term risk of ischaemic stroke and the clinical effects of antithrombotics on the risk of haemorrhagic stroke in patients with systemic lupus erythematosus(SLE).Methods A retrospective cohort study was conducted using a population-based database taken from Taiwan region Health Insurance Research Database.Patients with SLE between 2000 and 2008 were registered and matched with two controls by the index date,age,gender and Charlson Comorbidity Index(CCI).These subjects were followed until either stroke event or 31 December 2013.Adjusted HRs(aHRs)for strokes were estimated with Cox regression models,and the cumulative incidence of ischaemic stroke was analysed by log-rank test and Kaplan-Meier survival analysis.Results In total,8310 patients with SLE and 16620 patients without SLE were included.In general,patients with SLE had higher rates of ischaemic stroke(5.4%vs 3.3%)and haemorrhagic stroke(1.5%vs 0.6%)than in controls.In multivariate analysis adjusted to age,gender,CCI,urbanisation level and antithrombotics uses,aHRs of all strokes,ischaemic stroke and haemorrhagic stroke were 1.73(95%CI:1.54 to 1.94),1.65(95%CI:1.45 to 1.87)and 2.24(95%CI:1.71 to 2.95),respectively,in patients with SLE.Patients with SLE were significantly more likely to suffer ischaemic stroke than patients without SLE,even 10 years after SLE diagnosis(6.12%vs 3.50%,p<0.001).Antiplatelet use increased the risk of haemorrhagic stroke in SLE group(aHR=1.74,95%CI:1.18 to 2.57).Conclusions Patients with SLE are at greater risk of developing ischaemic stroke that lasts for 10 years.Antiplatelets should be carefully administered to prevent cardiovascular events in patients with SLE due to the risk of haemorrhagic stroke.

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分 类 号：R743.3[医药卫生—神经病学与精神病学]