肝巨噬细胞调控肝癌癌前病变恶变的研究进展  

Research advances in liver macrophages regulating malignant transformation of hepatic precancerous lesions

作　　者：闫瑞娟 焦俊喆 黄玉 闫曙光[2] 魏海梁 常占杰 郭英君[3] 李京涛 YAN Ruijuan;JIAO Junzhe;HUANG Yu;YAN Shuguang;WEI Hailiang;CHANG Zhanjie;GUO Yingjun;LI Jingtao(Liver Disease Hospital Ward One,The Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang,Shaanxi 712000,China;First Clinical Medical College,Shaanxi University of Chinese Medicine,Xianyang,Shaanxi 712000,China;Department of Infectious Diseases,People’s Hospital of Ningxia Hui Autonomous Region,Yinchuan 750002,China)

机构地区：[1]陕西中医药大学附属医院肝病医院一病区,陕西咸阳712000 [2]陕西中医药大学第一临床医学院,陕西咸阳712000 [3]宁夏回族自治区人民医院感染疾病科,银川750002

出　　处：《临床肝胆病杂志》2024年第5期1039-1043,共5页Journal of Clinical Hepatology

基　　金：国家自然科学基金(82174330);陕西省科技厅科研基金(2022JQ-965,2020ZDLSF05-15);陕西省科技厅创新团队(2022TD-55);陕西省中管局创新团队(2022-SLRH-LJ-002);咸阳市科技局科研基金(L2022ZDYFSF007);宁夏自然科学基金(2023AAC03510);陕西中医药大学学科创新团队建设项目(2019-YL05)。

摘　　要：肝巨噬细胞是肝脏中重要的免疫细胞,其通过极化为M1型和M2型,分别表达“促炎因子”和“抑炎因子”,进而发挥调控炎症损伤反应的作用。肝祖细胞恶变是肝癌癌前病变恶性进展的核心机制,其发生的关键因素是炎症损伤微环境的持续刺激,与M1/M2巨噬细胞极化密切相关。本综述主要围绕“巨噬细胞极化-慢性炎症-肝祖细胞恶变”关系进行探讨,为肝癌癌前病变的预防和治疗提供重要的理论依据。Liver macrophages are important immune cells in the liver,and they express proinflammatory factors and anti-inflammatory factors through polarization into M1 type and M2 type,respectively,thereby playing a role in regulating inflammatory damage response.The malignant transformation of hepatic progenitor cells is the core mechanism of the malignant progression of hepatic precancerous lesions,and its key factor is the continuous stimulation of inflammatory microenvironment,which is closely associated with M1/M2 macrophage polarization.This review mainly focuses on the association between macrophage polarization,chronic inflammation,and malignant transformation of hepatic progenitor cells,so as to provide a theoretical basis for the prevention and treatment of hepatic precancerous lesions.

关 键 词：癌 肝细胞 肝巨噬细胞 肝祖细胞恶变 

分 类 号：R735.7[医药卫生—肿瘤]