Wnt信号通路与肝再生的关系及其在肝脏疾病中的作用  

The relationship between the Wnt signaling pathway and liver regeneration and its role in liver diseases

作　　者：林玉培 刘晓萍 罗银冰 李飞燕 廖莹莹 莫世聪 毛德文[2] 蓝艳梅 LIN Yupei;LIU Xiaoping;LUO Yinbing;LI Feiyan;LIAO Yingying;MO Shicong;MAO Dewen;LAN Yanmei(Graduate School of Guangxi University of Chinese Medicine,Nanning 530001,China;Key Laboratory of Traditional Chinese Medicine Clinical Research,The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530023,China;Guangxi Key Laboratory of Molecular Biology in Traditional Chinese Medicine Prevention and Treatment,The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530023,China)

机构地区：[1]广西中医药大学研究生院,南宁530001 [2]广西中医药大学第一附属医院中医临床研究重点实验室,南宁530023 [3]广西中医药大学第一附属医院广西中医药防治医学分子生物重点实验室,南宁530023

出　　处：《临床肝胆病杂志》2024年第5期1050-1056,共7页Journal of Clinical Hepatology

基　　金：国家自然科学基金(81960841,82274434);广西自然科学基金(2020GXNSFBA297115,2023GXNSFAA026176);广西自然科学基金创新研究团队项目(2020GXNSFAA297070);广西高校中青年教师科研基础能力提升项目(2022KY0299);广西中医药大学校级一般硕士研究生创新项目(YCSY2022024)。

摘　　要：Wnt信号通路在维持肝脏内稳态和肝脏再生过程中扮演重要角色,在成熟的健康肝脏中,Wnt信号通路大多是不活跃的,但在细胞更新或再生过程中,以及在某些病理条件、疾病、癌前状态和癌症中,Wnt信号通路被持续过度激活。持续的肝细胞损伤常常会导致慢性肝病,如肝纤维化、肝硬化及肝癌等。本文概述了Wnt信号通路的基本结构特点,详细分析了其在多种肝脏疾病病理进展所扮演的重要角色,希望为临床防治肝脏疾病提供新思路。The Wnt signaling pathway plays an important role in maintaining liver homeostasis and liver regeneration.In healthy livers,the Wnt signaling pathway is mostly inactive,but it is continuously overactivated during cell renewal or regeneration processes,as well as in certain pathological conditions,diseases,precancerous states,and cancers.Persistent liver cell injury often leads to chronic liver diseases such as liver fibrosis,liver cirrhosis,and liver cancer.This article summarizes the basic structural features of the Wnt signaling pathway and analyzes its important role in the pathological progression of various liver diseases,so as to provide new ideas for the prevention and treatment of liver diseases in clinical practice.

关 键 词：肝疾病 肝再生 WNT信号通路 Β连环素 

分 类 号：R575[医药卫生—消化系统]