β-葡萄糖醛酸酶(GUS)在原发性肝内胆管结石形成中的作用  

Role ofβ-glucuronidase in the formation of primary intrahepatic stones

作　　者：李果 叶海军 徐至开 李文涛 徐承雷 李江[1] LI Guo;YE Haijun;XU Zhikai;LI Wentao;XU Chenglei;LI Jiang(Department of Hepatobiliary Surgery,The First Affiliated Hospital of Kunming Medical University,Kunming 650032,China)

机构地区：[1]昆明医科大学第一附属医院肝胆外科,昆明650032

出　　处：《临床肝胆病杂志》2024年第5期1057-1061,共5页Journal of Clinical Hepatology

基　　金：云南省科技厅-高校联合基金项目(202101AY070001-129)。

摘　　要：原发性肝内胆管结石(PIS)是我国西南地区高发和难治性疾病,对患者的生活造成极大的影响。胆道系统慢性感染产生的β-葡萄糖醛酸酶等代谢产物,在色素性结石的形成中起着重要作用,除细菌产生的外源性β-葡萄糖醛酸酶,肝内胆管细胞产生的内源性β-葡萄糖醛酸酶在结石的形成中亦扮演重要角色。本文就PIS发病机制中β-葡萄糖醛酸酶的作用研究进展予以分析,以期为PIS的防治提供可能的方式。Primary intrahepatic stones(PIS)is a refractory disease with a high incidence rate in Southwest China,which greatly affects the life of patients.Metabolites,such asβ-glucuronidase produced by chronic biliary tract infection,play an important role in the formation of pigmented stones.In addition to exogenousβ-glucuronidase produced by bacteria,endogenousβ-glucuronidase produced by intrahepatic bile duct cells also plays an important role in the formation of stones.This article analyzes the research advances in the role ofβ-glucuronidase in the pathogenesis of PIS,in order to provide a possible method for the prevention and treatment of PIS.

关 键 词：胆石 葡萄糖醛酸酶 病理过程 

分 类 号：R575.7[医药卫生—消化系统]