肿瘤特异性多肽探针及其在生物成像中的应用  

Tumor-specific Peptide Probes and the Applications in Bioimaging

作　　者：王博 蔡向东 肖建喜[1,2] Bo Wang;Xiangdong Cai;Jianxi Xiao(College of Chemistry and Chemical Engineering,Lanzhou University,Lanzhou 730000,China;Gansu Engineering Research Center of Medical Collagen,Lanzhou 730000,China)

机构地区：[1]兰州大学化学化工学院,兰州730000 [2]甘肃省医用胶原蛋白工程研究中心,兰州730000

出　　处：《化学学报》2024年第3期367-376,共10页Acta Chimica Sinica

基　　金：国家自然科学基金(No.22074057);甘肃省自然科学基金(Nos.20YF3FA025,23JRRA1096);中国博士后科学基金(No.2022M711449)资助。

摘　　要：肿瘤是由细胞、细胞外基质及微环境等多因素组成的复杂系统,不同因素在肿瘤的发生和发展中发挥关键作用.肿瘤细胞、细胞外基质及微环境的特异性分析对于肿瘤的精准诊断和靶向治疗至关重要.多肽探针具有特异性高、生物相容性好、组织穿透能力强和易于制备等优点,已被广泛用于肿瘤的特异性成像研究.本文综述了多肽探针对肿瘤细胞、免疫细胞等细胞靶点的特异性成像;并介绍了以胶原蛋白、纤维蛋白等外基质蛋白为靶点的肿瘤特异性多肽探针的成像研究.本文还总结了对肿瘤微环境中弱酸性、高酶活性等因素响应的肿瘤特异性多肽探针及其生物成像应用.最后,本文总结并讨论了肿瘤特异性多肽探针所面临的挑战与机遇,展望了其在肿瘤精准诊断和个性化治疗领域的前景.The tumor is a complex system composed of various elements, encompassing cells, extracellular matrix, and the tumor microenvironment. Each of these distinct factors plays a pivotal role in the development and progression of tumors. The specific analysis of tumor-associated cells, extracellular matrix, and tumor microenvironment is of paramount importance for precise diagnosis and targeted therapy of tumors. Peptide probes have gained substantial prominence in investigations focused on tumor-specific imaging, primarily attributed to their notable attributes, including high specificity, biocompatibility, tissue-penetrating capabilities, and straightforward preparation processes. This review comprehensively summarizes the peptide probes for specific imaging of tumor-associated cells. The specific recognition of cells was by binding various cellular markers, such as the epidermal growth factor receptor (EGFR), vascular endothelial growth factor receptor (VEGFR), and folate receptor (FRα) for tumor cells. Additionally, the biomarkers include CD206, neurokinin-1 receptor (NK-1R), and CD11c for immune cells, along with nucleolin and integrins for tumor vascular endothelial cells. Furthermore, this comprehensive review encapsulates peptide probes designed for the specific targeting of extracellular matrix proteins and their applications in tumor-specific imaging. The focal points among these protein targets encompass pathological collagen, matrix metalloproteinases, and fibronectin. Of particular significance is the potential of pathological collagen as a highly promising extracellular matrix target for achieving tumor-specific imaging. The review comprehensively outlines tumor-specific peptide probes responsive to various factors within the tumor microenvironment. Commonly encountered responsive factors in the tumor microenvironment include mild acidity (pH), heightened enzyme activity, such as matrix metalloproteinases and cathepsin, and elevated levels of oxidative stress. It further explores their versatile applicat

关 键 词：肿瘤 肿瘤微环境 细胞外基质 多肽探针 生物成像 

分 类 号：R73-3[医药卫生—肿瘤] O657.3[医药卫生—临床医学]