激光光动力疗法联合靶向治疗在晚期贲门-胃底癌中的应用效果  

Application Effect of Laser Photodynamic Therapy Combined with Targeted Therapy in Advanced Cardia-fundus Carcinoma

作　　者：袁毫[1] 逯琳 YUAN Hao;LU Lin(Anyang Traditional Chinese Medicine Hospital,Anyang 455000,China;不详)

机构地区：[1]安阳市中医院,河南安阳455000

出　　处：《中外医学研究》2024年第13期63-66,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：安阳市科技攻关项目(2022C01SF098)。

摘　　要：目的:观察激光光动力疗法(LPDT)联合靶向治疗在晚期贲门-胃底癌(CFGC)中的应用效果。方法:选取2020年4月—2022年5月安阳市中医院收治的62例晚期CFGC患者作为研究对象。根据随机数表法将其分为对照组和观察组,各31例。观察组给予靶向治疗联合LPDT,对照组给予靶向治疗。比较两组治疗后食管梗阻程度、近期疗效、不良反应、生存质量,随访3个月、6个月、9个月、12个月生存率。结果:治疗后,观察组食管梗阻程度显著优于对照组,差异有统计学意义(P<0.05)。观察组总有效率为93.55%,明显高于对照组的74.19%,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。观察组生存质量改善率为61.29%,明显高于对照组的35.48%,差异有统计学意义(P<0.05)。观察组治疗后12个月生存率为58.06%,显著高于对照组的32.26%,差异有统计学意义(P<0.05)。结论:LPDT联合靶向治疗可改善晚期CFGC梗阻症状,提高近期疗效,并有助于延长生存期,改善患者生存质量。Objective:To observe the application effect of laser photodynamic therapy(LPDT)combined with targeted therapy in advanced cardia-fundus carcinoma(CFGC).Method:Sixty-two patients with advanced CFGC admitted to Anyang Traditional Chinese Medicine Hospital from April 2020 to May 2022 were selected as the study objects.They were divided into control group and observation group according to random number table method,with 31 cases in each group.The observation group was given targeted therapy combined with LPDT,and the control group was given targeted therapy.The degree of esophageal obstruction,short-term efficacy,adverse reactions and quality of life after treatment,and the survival rates were followed up at 3,6,9 and 12 months were compared between the two groups.Result:After treatment,the degree of esophageal obstruction in the observation group was significantly better than that in the control group,the differences were statistically significant(P<0.05).The total effective rate of observation group was 93.55%,which was significantly higher than 74.19%of control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).The improvement rate of quality of life in the observation group was 61.29%,which was significantly higher than 35.48%in the control group,and the difference was statistically significant(P<0.05).The survival rate follow up for 12 months of observation group was 58.06%,which was significantly higher than 32.26%of control group,and the difference was statistically significant(P<0.05).Conclusion:LPDT combined targeted therapy can improve the symptoms of advanced CFGC obstruction,improve the short-term efficacy,and help to prolong survival and improve the quality of life of patients.

关 键 词：光动力 靶向治疗 晚期贲门-胃底癌 效果 

分 类 号：R735.2[医药卫生—肿瘤]