奥曲肽联合胃镜治疗消化性溃疡伴出血患者的临床效果  

Clinical Efficacy of Octreotide Combined with Gastroscopy in the Treatment of Peptic Ulcer Patients with Bleeding

作　　者：贺鹏美 HE Pengmei(Qujing No.1 Hospital,Qujing 655000,China)

机构地区：[1]曲靖市第一人民医院,云南曲靖655000

出　　处：《中外医学研究》2024年第13期112-116,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:分析奥曲肽联合胃镜治疗消化性溃疡伴出血患者的临床效果。方法:选择2021年1月—2023年1月曲靖市第一人民医院收治的200例消化性溃疡伴出血患者作为研究对象,根据治疗方法的不同分为对照组和观察组,各100例。对照组采用胃镜治疗,观察组在对照组的基础上加用奥曲肽治疗。比较两组的症状缓解时间、住院时间、疼痛程度、炎症因子指标、生活质量。结果:治疗后,观察组腹痛缓解时间、呕血停止时间、住院时间均短于对照组,差异有统计学意义(P<0.05);治疗后24 h、48 h,观察组视觉模拟评分法(VAS)评分均低于对照组,差异有统计学意义(P<0.05);治疗后,观察组白细胞介素-2(IL-2)高于对照组,白细胞介素-6(IL-6)低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组健康调查简表(SF-36)各维度评分均高于对照组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:奥曲肽联合胃镜治疗消化性溃疡伴出血患者可较快缓解患者的呕血和疼痛症状,调节炎症因子指标,提升患者生活质量,促进患者早日康复出院。Objective:To analyze the clinical effect of Octreotide combined with gastroscopy in the treatment of peptic ulcer with bleeding.Method:A total of 200 patients with peptic ulcer with bleeding admitted to the Qujing No.1 Hospital from January 2021 to January 2023 were selected as the study objects,and they were divided into control group and observation group according to different treatment methods,with 100 cases in each group.The control group was treated with gastroscopy,and the observation group was treated with Octreotide on the basis of the control group.Symptom remission time,hospital stay,pain degree,inflammatory factor index and quality of life were compared between the two groups.Result:After treatment,the time of abdominal pain relief,hematemesis stop time and hospital stay in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).At 24 h and 48 h after treatment,visual analogue scale(VAS)scores in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,interleukin-2(IL-2)in observation group was higher than that in control group,interleukin-6(IL-6)was lower than that in control group,the differences were statistically significant(P<0.05).After treatment,the MOS item short from health survey(SF-36)scores in each dimension of the observation group were higher than those of the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Octreotide combined with gastroscopy in the treatment of peptic ulcer patients with bleeding can quickly relieve the hematemesis and pain symptoms of patients,regulate the indicators of inflammatory factors,improve the quality of life of patients,and promote the early recovery and discharge of patients.

关 键 词：消化性溃疡 上消化道出血 胃镜 奥曲肽 

分 类 号：R573.1[医药卫生—消化系统]