克隆性造血与心血管疾病相关性的研究进展  

Correlation Between Clonal Hematopoiesis and Cardiovascular Disease

作　　者：赵娜 符珍珍 兰雨 张锦[2] 马志远 ZHAO Na;FU Zhenzhen;LAN Yu;ZHANG Jin;MA Zhiyuan(The First Clinical Medical College of Lanzhou University,Lanzhou 730000,Gansu,China;Department of Cardiovascular Medicine,The First Hospital of Lanzhou University,Key Laboratory of Cardiovascular Diseases in Gansu Province,Lanzhou 730000,Gansu,China;Department of Geriatrics,The First Hospital of Lanzhou University,Lanzhou 730000,Gansu,China)

机构地区：[1]兰州大学第一临床医学院,甘肃兰州730000 [2]兰州大学第一医院心血管内科甘肃省心血管疾病重点实验室,甘肃兰州730000 [3]兰州大学第一医院老年医学科,甘肃兰州730000

出　　处：《心血管病学进展》2024年第4期355-358,367,共5页Advances in Cardiovascular Diseases

基　　金：甘肃省自然科学基金(220365881344,186937634816)。

摘　　要：造血系统中体细胞突变的非恶性克隆扩增被称为克隆性造血,是在驱动基因突变后突变白细胞比例增加的过程。克隆性造血的遗传模式包括白血病驱动基因突变、常染色体镶嵌染色体交替和性染色体缺失。新近研究指出,由白血病驱动基因突变或白细胞Y染色体镶嵌缺失引起的克隆性造血,会影响各种心血管疾病(包括动脉粥样硬化、心力衰竭、心脏纤维化)的发生发展。越来越多的证据表明,克隆性造血是心血管疾病的一种新机制,也是一类新的危险因素,与传统危险因素同等重要。现分析克隆性造血的遗传模式,对其与心血管疾病之间的相关性展开综述分析。Non-malignant clonal amplification of somatic cell mutation in hematopoietic system is called clonal hematopoiesis,which is a process of increasing the proportion of mutant white blood cells after driving gene mutation.The genetic patterns of clonal hematopoiesis include leukemia driver gene mutation,autosomal mosaic chromosome alternation and sex chromosome deletion.Recent studies have pointed out that clonal hematopoiesis caused by leukemia driver gene mutation or white blood cell Y chromosome mosaic deletion will affect the occurrence and development of various cardiovascular disease(including atherosclerosis,heart failure and cardiac fibrosis).More and more evidence shows that clonal hematopoiesis is a new mechanism of cardiovascular disease and a new kind of risk factor,which is as important as traditional risk factors.Therefore,this paper analyzes the genetic model of clonal hematopoiesis and summarizes the correlation between clonal hematopoiesis and cardiovascular disease.

关 键 词：克隆性造血 心血管疾病 体细胞突变 Y染色体缺失 炎症反应 

分 类 号：R54[医药卫生—心血管疾病]