非嗜酸细胞性食管炎的嗜酸细胞性胃肠病研究进展  

Advances on research in the field of eosinophilic gastrointestinal disorders beyond eosinophilic esophagitis

作　　者：杜志荣 支玉香 DU Zhirong;ZHI Yuxiang(Department of Allergy,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic Disease,National Clinical Research Center for Dermatologic and Immunologic Diseases,Beijing 100730,China)

机构地区：[1]中国医学科学院,北京协和医学院,北京协和医院变态(过敏)反应科,过敏性疾病精准诊疗研究北京市重点实验室,国家皮肤与免疫疾病临床医学研究中心,北京100730

出　　处：《中华临床免疫和变态反应杂志》2024年第2期200-208,共9页Chinese Journal of Allergy & Clinical Immunology

基　　金：中国医学科学院医学与健康科技创新工程2021年“揭榜挂帅”项目,中国罕见病的精准诊疗研究(2021-1-I2M-003)。

摘　　要：嗜酸细胞性胃肠病(eosinophilic gastrointestinal disorders,EGIDs)是一种免疫介导的慢性疾病,以嗜酸性粒细胞浸润胃肠道为组织学特征。其中研究最多的是嗜酸细胞性食管炎(eosinophilic esophagitis,EoE)。但近年来,非EoE的EGIDs患病率逐渐增加,其病因和发病机制尚不明确,超敏反应及Th2型免疫应答在其中发挥重要作用。临床表现取决于嗜酸性粒细胞浸润的胃肠壁部位和深度,实验室检查、影像学表现和内窥镜检查为其诊断提供了重要依据,病理组织学检查是其诊断的基石。饮食疗法和皮质类固醇激素是EGIDs的主要治疗方法,其他治疗方法包括肥大细胞稳定剂、白三烯拮抗剂、抗组胺药、免疫调节剂和生物制剂,其中生物制剂为难治性或皮质类固醇依赖型非EoE EGIDs患者提供了新的治疗选择。Eosinophilic gastrointestinal disorders(EGIDs)is one group of immune-mediated chronic diseases characterized by eosinophil infiltration in gastrointestinal tract.Eosinophilic esophagitis(EoE)is one of the most adequately studied diseases.Prevalence of non-EoE EGIDs has increased gradually in recent years.Etiology and pathogenesis of non-EoE EGIDs remains unknown.Hypersensitivity and Th2-type immune response play important roles in pathogenesis.Clinical manifestations depend on location and depth of eosinophil infiltrations in gastrointestinal wall.Laboratory examination,imaging findings and endoscopy can provide important information for diagnosis and pathologic results of tissue biopsy is the cornerstone for diagnosis.Dietary therapy and corticosteroids are major methods for treatment.Other treatments include mast cell stabilizers,leukotriene antagonists,antihistamines,immunomodulators and biological agents.Biological agents provide novel therapeutic options for refractory or corticosteroid-dependent non-EoE EGIDs patients.

关 键 词：嗜酸细胞性胃肠病 发病机制 诊断 治疗 生物制剂 

分 类 号：R571[医药卫生—消化系统]