静息态功能磁共振成像在青少年精神分裂症中的应用进展  

Advances in the application of resting-state functional magnetic resonance imaging in adolescent-onset schizophrenia

作　　者：王露 刘芮杉 廖娟 李宏伟 卓丽华 WANG Lu;LIU Ruishan;LIAO Juan;LI Hongwei*;ZHUO Lihua*(Medical Imaging College,North Sichuan Medical College,Nanchong 637000,China;Department of Radiology,the Third Hospital of Mianyang,Sichuan Mental Health Center,Mianyang 621000,China)

机构地区：[1]川北医学院医学影像学院,南充637000 [2]绵阳市第三人民医院(四川省精神卫生中心)放射科,绵阳621000

出　　处：《磁共振成像》2024年第5期168-174,180,共8页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家重点研发计划项目(编号:2022YFC2009901-05,2022YFC2009900)。

摘　　要：青少年精神分裂症(adolescent-onset schizophrenia,AOS)属于早发性精神分裂症的范畴,是指发病年龄在13~18岁之间的精神分裂症,与成人发病的精神分裂症相比,其症状更不典型,程度更严重,对抗精神病药物的治疗反应更差,并且其病因及发病机制至今尚不明确。静息态功能MRI(resting-state functional MRI,rs-fMRI)是一种操作便捷、无创客观且受试者易于配合的MRI技术,它能够从局部和整体反映脑神经元的自发性活动情况,为AOS神经病理学机制研究提供了强有力的手段。本文从功能分离分析和功能整合分析两方面展开,围绕rs-fMRI在AOS研究中应用的最新进展进行综述,探讨了当前研究的不足之处,并对未来进一步研究的方向进行了展望,旨在为进一步探索精神分裂症的病理生理学机制提供一定线索和依据。Adolescent-onset schizophrenia belongs to the category of early-onset schizophrenia,which refers to schizophrenia with onset between the ages of 13-18 years old.Compared with adult-onset schizophrenia,its symptoms are more atypical and severe,its response to antipsychotic medications is poorer,and its etiology and pathogenesis are not yet clear.Resting-state functional MRI(rs-fMRI)is a convenient,noninvasive and objective MRI technique that is easy for subjects to cooperate with,and it can reflect the spontaneous activity of brain neurons both locally and holistically,providing a powerful means for the study of the neuropathological mechanisms of AOS.In this paper,we review the latest progress in the application of rs-fMRI in the study of AOS from the aspects of functional segregation analysis and functional integration analysis,discuss the shortcomings of the current study,and look forward to the direction of further research in the future,with the aim of providing certain clues and bases for further exploring the pathophysiological mechanisms of schizophrenia.

关 键 词：精神分裂症 青少年 磁共振成像 静息态功能磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749.1[医药卫生—诊断学]