利钠肽、cGMP与急性缺血性脑卒中的相关研究进展  

Research advances in the association of natriuretic peptides and cyclic guanosine monophosphate with acute isch⁃emic stroke

作　　者：李家任 刘嘉禹 张佳乐(综述) 石瑞丽[1] 郝肖琼(审校) LI Jiaren;LIU Jiayu;ZHANG Jiale(Department of Physiology,Baotou Medical College,Baotou 014040,China)

机构地区：[1]包头医学院生理学教研室,内蒙古包头014040

出　　处：《中风与神经疾病杂志》2024年第5期470-475,共6页Journal of Apoplexy and Nervous Diseases

基　　金：国家自然科学基金项目(81960734);包头医学院博士科研启动基金(BSJJ201806);包头医学院科学研究基金项目(BYJJ-QM201905)。

摘　　要：利钠肽家族成员(NPs)与缺血性脑卒中(AIS)密切相关。既往研究证实NPs具有促进血管舒张、抗炎和抗凋亡等有益作用。其中心房钠肽(ANP)和脑钠肽(BNP)在心血管引起的有益作用与A型利钠肽受体(NPR-A)/环磷酸腺苷(cGMP)信号传导途径有关。随着C型利钠肽(CNP)及其依赖性受体(NPR-B)在脑组织中的发现,NPs为缺血性脑卒中的诊断和治疗提供新的思路。近期的研究已经证实ANP、BNP和CNP及其同源性受体对缺血性脑卒中引起的神经元损伤产生有益的影响。然而,NPs在其中介导的通路机制仍不清楚。本综述旨在对NPs、cGMP和急性缺血性脑卒中(AIS)的相关研究进行总结,为后期NPs在AIS的相关研究提供借鉴。Natriuretic peptides(NPs)are closely associated with acute ischemic stroke(AIS),and previous studies have shown that NPs have the beneficial effects of promoting vasodilation and inhibiting inflammation and apoptosis.The beneficial cardiovascular effects of atrial natriuretic peptide(ANP)and brain natriuretic peptide(BNP)are associated with the natriuretic peptide receptor A/cyclic guanosine monophosphate(cGMP)signaling pathway.With the discovery of C-type natriuretic peptide(CNP)and its dependent receptor natriuretic peptide receptor B in brain tissue,NPs provide new ideas for the diagnosis and treatment of AIS.Recent studies have confirmed the beneficial effects of ANP,BNP,CNP,and their homologous receptors on neuronal damage induced by AIS;however,the specific mechanism of pathways mediated by NPs remains unknown.This article summarizes the studies on NPs,cGMP,and AIS,in order to provide a reference for subsequent studies on NPs in AIS.

关 键 词：利钠肽 急性脑缺血 CGMP 

分 类 号：R743.3[医药卫生—神经病学与精神病学]