修饰后的间充质干细胞在神经退行性疾病中应用的研究进展  

Research progress on the application of modified mesenchymal stem cells in neurodegenerative diseases

作　　者：张丽 黄南渠 罗勇 Zhang Li;Huang Nanqu;Luo Yong(Department of Neurology,the Third Affiliated Hospital of Zunyi Medical University,the First People’s Hospital of Zunyi,Zunyi Guizhou 563000,China;National Drug Clinical Trial Institution,the Third Affiliated Hospital of Zunyi Medical University,the First People’s Hospital of Zunyi,Zunyi Guizhou 563000,China)

机构地区：[1]遵义医科大学第三附属医院,遵义市第一人民医院.神经内科,贵州遵义563000 [2]遵义医科大学第三附属医院,遵义市第一人民医院药物临床试验机构办公室,贵州遵义563000

出　　处：《遵义医科大学学报》2024年第5期531-539,546,共10页Journal of Zunyi Medical University

基　　金：国家自然科学基金资助项目(NO:82160858);贵州省科技计划项目[NO:黔科合基础-ZK(2021)-570]。

摘　　要：间充质干细胞(MSCs)是一种可以从骨髓和脂肪组织以及脐带和胎盘等多种生物组织中分离出来的细胞。MSCs具有广泛的增殖、多向分化的能力,具有营养、归巢、迁移和免疫调节功能。近年来,MSCs在神经系统退行性疾病的治疗研究中得到广泛应用。使用不同方法修饰后的MSCs治疗效果大大提升,移植后的MSCs细胞存活率增高,增殖和分化能力也有所提高。研究者采用多种修饰方法如基因工程、小分子修饰、溶瘤病毒处理等方法对MSCs进行修饰,本文就MSCs不同的修饰方法及其在神经退行性疾病研究中的应用进行综述。Objective Mesenchymal stem cells(MSCs)are cells that can be isolated from various biological tissues such as bone marrow and adipose tissue,as well as the umbilical cord and placenta.MSCs have the ability of extensive multiplication and multi-way differentiation,and have the functions of nutrition,nesting,migration and immunoregulation.In recent years,MSCs have been widely used in the treatment of degenerative diseases of the nervous system.And the therapeutic effect of MSCs modified with different methods is greatly improved.The survival rate of transplanted MSCs cells is increased,and their proliferation and differentiation abilities are also improved,a variety of methods for modifying MSCs such as genetic engineering,small molecule pretreatment,tumor virus treatment and other methods are used to modify MSCs.This article reviews the different modification methods of MSCs and their applications in the study of neurodegenerative diseases.

关 键 词：间充质干细胞 修饰 神经退行性疾病 

分 类 号：R741.05[医药卫生—神经病学与精神病学]